Title:
イソプレニル-S-システイニルメチルトランスフェラーゼの阻害のための酸模倣化合物
Document Type and Number:
Japanese Patent JP2011505384
Kind Code:
A
Abstract:
Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, compounds of the present invention act as inhibitors of edema, inhibitors of erythema and inhibitors of MPO (myeloperoxidase), pharmaceutical compositions containing the same compounds and the use thereof for the treatment of diseases that may benefit from edema, erythema and MPO inhibition, such as inflammation (acute or chronic), asthma, autoimmune diseases, and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis and small airways disease, etc.), inflammatory responses of the immune system, skin diseases (e.g., reducing acute skin irritation for patients suffering from rosacea, atopic dermatitis, seborrheic dermatitis, psoriasis), irritable bowel syndrome (e.g., Chron's disease and ulcerative colitis, etc.), and central nervous system disorders (e.g., Parkinson's disease).
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Inventors:
Lee, Sun-Yab
Perez, edwald
Rapport, keshaba
Sanga Daran, Gopal
Stock, Gregory Bee.
Stock, Jeffrey Bee.
Stock maxwell
Boronkov, Michael
Wollanine, Peter
Perez, edwald
Rapport, keshaba
Sanga Daran, Gopal
Stock, Gregory Bee.
Stock, Jeffrey Bee.
Stock maxwell
Boronkov, Michael
Wollanine, Peter
Application Number:
JP2010536233A
Publication Date:
February 24, 2011
Filing Date:
December 02, 2008
Export Citation:
Assignee:
Signum Biosciences, Inc.
International Classes:
C07C323/25; A61K31/16; A61K31/18; A61K31/27; A61K31/41; A61P1/04; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P17/08; A61P25/00; A61P25/16; A61P29/00; A61P37/02; A61P37/08; C07C323/60; C07D257/04
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita