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Title:
ACRIDONE-BASED COMPOUND
Document Type and Number:
Japanese Patent JPH09249650
Kind Code:
A
Abstract:

To obtain a new acridone-based compound having activity to inhibit binding of IgE receptor γ-chain to tylosin kinase at 72 kDa, thus useful for preventing/treating asthma, allergic rhinitis, atopic rhinitis, nettle rash, etc.

This new compound is an acridone derivative (pharmacologically permissible salt thereof) of formula I {R1 to R6 are each H, OH, cyano, nitro, amino, a halogen, lower alkyl, lower alkoxy, etc.; Y is a group of the formula A-Z [A is of the formula (CH2)t-(B)m-(CH2)n ((m) is 0 or 1; (t) and (n) are each an integer or 0-6; B is a lower alkylene, etc.); Z is cyano, carboxyl, etc.]; D is 0 atom or S atom}, e.g. 10-(3-aminopropyl)-8-carboxymethyl-3,4-dimethyl-9- acridone n-heptyl ester. The compound of formula I is obtained by cyclizing a carboxydiphenylamine formed by Ullman reaction into a compound of formula II which is, in turn, subjected to condensation reaction, Gabriel synthesis, etc.


Inventors:
MIYAMOTO MITSUAKI
YOSHIUCHI TATSUYA
SATO KEIZO
KAINO MASATO
TAKASHIMA YOSHIHIRO
MORIYA KATSUHIRO
SAKUMA YOSHINORI
YAMADA KOJI
HARADA KOKICHI
NISHIZAWA YUKIO
KOBAYASHI SEIICHI
OKITA MAKOTO
KATAYAMA KOICHI
Application Number:
JP26166996A
Publication Date:
September 22, 1997
Filing Date:
October 02, 1996
Export Citation:
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Assignee:
EISAI CO LTD
International Classes:
C07D219/14; A61K31/47; A61K31/473; A61K31/495; A61K31/52; A61K38/00; A61K38/46; A61P1/00; A61P11/00; A61P17/00; A61P27/16; A61P37/08; A61P43/00; C07D401/12; C07D405/06; C07D405/12; (IPC1-7): C07D219/14; A61K31/47; A61K31/495; A61K31/52; A61K38/00; A61K38/46; C07D401/12; C07D405/06; C07D405/12