Title:
標的型癌ナノ治療に用いる、活性剤が負荷された活性化PLGAナノ粒子製剤
Document Type and Number:
Japanese Patent JP2010524859
Kind Code:
A
Abstract:
The present invention includes compositions and methods of making an activated polymeric nanoparticle for targeted drug delivery that includes a biocompatible polymer and an amphiphilic stabilizing agent non-covalently associated with a spacer compound that includes at least one electrophile that selectively reacts with any nucleophilic on a targeting agent and places the targeting agent on the exterior surface of a biodegradable nanoshell, wherein an active agent is loaded with the nanoshell.
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Inventors:
Braden Arthur R. C.
Vishwanatha Jembur Kay.
Vishwanatha Jembur Kay.
Application Number:
JP2010503258A
Publication Date:
July 22, 2010
Filing Date:
April 11, 2008
Export Citation:
Assignee:
UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH
International Classes:
A61K31/12; A61K9/14; A61K39/395; A61K45/00; A61K47/32; A61K47/34; A61K51/00
Foreign References:
| WO2006080951A2 | 2006-08-03 | |||
| WO2007034479A2 | 2007-03-29 |
Attorney, Agent or Firm:
Masaki Hirota