HCV阻害剤としてのアシルジヒドロピロール誘導体

Japanese Patent JP2007533693

A

Novel anti-viral agents of Formula (I) in which: A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, C1-6alkyl, aryl, heteroaryl or heterocyclyl; G represents hydrogen or C1-6alkyl optionally substituted by one or more substituents selected from halo, OR<1>, SR<1>, C(O)NR<2>R<3>, CO2H, C(O)R<4>, CO2R<4>, NR<2>R<3>, NHC(O)R<4>, NHCO2R<4>, NHC(O)NR<5>R<6>, SO2NR<5>R<6>, SO2R<4>, nitro, cyano, aryl, heteroaryl and heterocyclyl; R<1> represents hydrogen, C1-6alkyl, arylalkyl, or heteroarylalkyl; R<2> and R<3> are independently selected from hydrogen, C1-6alkyl, aryl and heteroaryl; or R<2> and R<3> together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; R<4> is selected from the group consisting of C1-6alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; R<5> and R<6> are independently selected from the group consisting of hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; or R<5> and R<6> together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; and J represents C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof; provided that when A is esterified to form -OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl; processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.

David High
Martin John Slater

JP2007508842A

November 22, 2007

April 20, 2005

Click for automatic bibliography generation  

GLAXO GROUP LIMITED

C07D417/04; A61K31/427; A61P31/12; A61P31/14; C07D417/14

Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita

Previous Patent: JP2007533692

Next Patent: 乾燥粉末医薬組成物、その製造方法、およびその組成物から得られる安定�...