ACYLATED INDANYL AMINE AND USE THEREOF AS PHARMACEUTICAL

Japanese Patent JP2010100622

A

To provide a compound that upregulates manifestation of endothelial NO-synthase.

There are provided acylated indanyl amines represented by general formula (I) [wherein R1 to R4 are each independently selected from the group consisting of H, an unsubstituted or substituted 1-16C alkyl at one or more positions and the like; A is selected from the group consisting of CH2, CHOH and a CH-(1-3C alkyl); B is selected from the group consisting of CH2 and a CH-(1-3C alkyl); and R5 indicates an aryl group or a heteroaryl group], its pharmaceutically acceptable salt and the like and a pharmaceutical preparation containing these for curing particularly cardiovascular disorder.

STROBEL HARTMUT
WOHLFART PAULUS
SAFAROVA ALENA
WALSER ARMIN
SUZUKI TERI
DHARANIPRAGADA RAMALINGA M
SCHOENAFINGER KARL

JP2009244620A

May 06, 2010

October 23, 2009

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SANOFI AVENTIS DEUTSCHLAND

C07C233/04; A61K9/02; C07C233/65; A61K9/06; A61K9/08; A61K9/10; A61K9/107; A61K9/12; A61K9/16; A61K9/20; A61K9/28; A61K9/30; A61K9/36; A61K9/48; A61K9/50; A61K9/72; A61K31/165; A61K31/166; A61K31/18; A61K31/194; A61K31/222; A61K31/341; A61K31/343; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/40; A61K31/404; A61K31/405; A61K31/415; A61K31/416; A61K31/4172; A61K31/4184; A61K31/4192; A61K31/42; A61K31/4245; A61K31/427; A61K31/433; A61K31/435; A61K31/4365; A61K31/437; A61K31/44; A61K31/4406; A61K31/4409; A61K31/4425; A61K31/4439; A61K31/455; A61K31/47; A61K31/473; A61K31/4965; A61K31/497; A61K31/498; A61K31/501; A61K31/502; A61K31/505; A61K31/538; A61K31/5513; A61P1/16; A61P3/10; A61P7/02; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P15/10; A61P19/10; A61P25/28; A61P43/00; C07C233/58; C07C233/64; C07C233/66; C07C233/67; C07C233/74; C07C233/76; C07C235/42; C07C235/44; C07C235/54; C07C235/82; C07C235/84; C07C237/28; C07C237/30; C07C237/38; C07C237/42; C07C237/52; C07C255/57; C07C255/60; C07C309/04; C07C309/66; C07C309/73; C07C311/08; C07C311/16; C07C311/21; C07C311/42; C07C317/44; C07C323/42; C07C323/56; C07C323/62; C07D207/325; C07D207/327; C07D207/34; C07D209/08; C07D209/42; C07D213/56; C07D213/81; C07D213/82; C07D215/48; C07D215/52; C07D219/04; C07D231/14; C07D231/56; C07D233/90; C07D235/08; C07D237/28; C07D239/26; C07D239/42; C07D241/24; C07D241/44; C07D243/14; C07D249/04; C07D249/06; C07D249/18; C07D261/18; C07D265/36; C07D271/08; C07D277/20; C07D277/56; C07D285/06; C07D295/12; C07D295/185; C07D307/68; C07D307/78; C07D307/79; C07D307/84; C07D307/85; C07D317/60; C07D317/68; C07D319/16; C07D319/18; C07D333/24; C07D333/38; C07D333/40; C07D333/68; C07D333/70; C07D401/06; C07D403/04; C07D405/04; C07D471/04; C07D495/04

JP4317689B2	2009-08-19
JPH05505199A	1993-08-05
JPH10500106A	1998-01-06
JP2004518719A	2004-06-24
JP4317689B2	2009-08-19

WO2002024631A1	2002-03-28
WO2000075114A1	2000-12-14
WO2002024631A1	2002-03-28

JPN6012030927; Ｊｏｕｒｎａｌ　ｏｆ　Ｍａｔｈｅｍａｔｉｃａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４４, 2001, ｐ．２６３８-４０
JPN6012030928; Ｂｕｌｌｅｔｉｎ　ｏｆ　ｔｈｅ　Ｋｏｒｅａｎ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ Ｖｏｌ．２２，　Ｎｏ．４, 2001, ｐ．４０１４
JPN6012030924; Ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ．　Ｐｅｒｋｉｎ　Ｔｒａｎｓａｃｔｉｏｎｓ．　１ Ｎｏ．１８, 2000, ｐ．３０９６-３１０６
JPN6012030925; Ｔｅｔｒａｈｅｄｒｏｎ　Ｌｅｔｔｅｒｓ Ｖｏｌ．３９, 1998, ｐ．４９７-５００
JPN6012030926; Ｊｕｓｔｕｓ　Ｌｉｅｂｉｇｓ　Ａｎｎａｌｅｎ　ｄｅｒ　Ｃｈｅｍｉｅ Ｖｏｌ．７４３, 1971, ｐ．４２-９
JPN6012030927; Ｊｏｕｒｎａｌ　ｏｆ　Ｍａｔｈｅｍａｔｉｃａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４４, 2001, ｐ．２６３８-４０
JPN6012030928; Ｂｕｌｌｅｔｉｎ　ｏｆ　ｔｈｅ　Ｋｏｒｅａｎ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ Ｖｏｌ．２２，　Ｎｏ．４, 2001, ｐ．４０１４

Junji Yuda
Shoji Miwa
Noriyuki Takebayashi

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