アシル化インダニルアミンおよび医薬としてのその使用

Japanese Patent JP5215975

B2

The present invention relates to acylated indanyl amines according to the general formula (I) wherein R1-R4 have the meanings given in the description, A is CH2, CHOH or CH—(C1-C3-alkyl), B is CH2 or CH—(C1-C3-alkyl), and R5 is an aryl or heteroaryl group, possibly substituted by the substituents listed in the description. These compounds are useful in the upregulation of endothelial nitric oxide synthase (eNOS), and may therefore be useful for the manufacture of medicaments for the treatment of cardiovascular diseases, stable or unstable angina pectoris, coronary heart disease, Prinzmetal angina, acute coronary syndrome, heart failure, myocardial infarction, stroke, thrombosis, peripheral artery occlusive disease, endothelial dysfunction, atherosclerosis, restenosis, endothelial damage after PTCA, hypertension, essential hypertension, pulmonary hypertension, secondary hypertension, renovascular hypertension, chronic glomerulonephritis, erectile dysfunction, ventricular arrhythmia, diabetes or diabetes complications, nephropathy or retinopathy, angiogenesis, asthma bronchiale, chronic renal failure, cirrhosis of the liver, osteoporosis, restricted memory performance, a restricted ability to learn, or for the lowering of cardiovascular risk of postmenopausal women or after intake of contraceptives.

Hartmut Straubel
Pauls Wohlfalt
Arena safarova
Armin Walther
Terri Suzuki
Lamaringa M. Darrani Pragada
Karl Schenafinger

JP2009244620A

June 19, 2013

October 23, 2009

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Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung

C07C233/04; A61K9/02; C07C233/65; A61K9/06; A61K9/08; A61K9/10; A61K9/107; A61K9/12; A61K9/16; A61K9/20; A61K9/28; A61K9/30; A61K9/36; A61K9/48; A61K9/50; A61K9/72; A61K31/165; A61K31/166; A61K31/18; A61K31/194; A61K31/222; A61K31/341; A61K31/343; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/40; A61K31/404; A61K31/405; A61K31/415; A61K31/416; A61K31/4172; A61K31/4184; A61K31/4192; A61K31/42; A61K31/4245; A61K31/427; A61K31/433; A61K31/435; A61K31/4365; A61K31/437; A61K31/44; A61K31/4406; A61K31/4409; A61K31/4425; A61K31/4439; A61K31/455; A61K31/47; A61K31/473; A61K31/4965; A61K31/497; A61K31/498; A61K31/501; A61K31/502; A61K31/505; A61K31/538; A61K31/5513; A61P1/16; A61P3/10; A61P7/02; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P15/10; A61P19/10; A61P25/28; A61P43/00; C07C233/58; C07C233/64; C07C233/66; C07C233/67; C07C233/74; C07C233/76; C07C235/42; C07C235/44; C07C235/54; C07C235/82; C07C235/84; C07C237/28; C07C237/30; C07C237/38; C07C237/42; C07C237/52; C07C255/57; C07C255/60; C07C309/04; C07C309/66; C07C309/73; C07C311/08; C07C311/16; C07C311/21; C07C311/42; C07C317/44; C07C323/42; C07C323/56; C07C323/62; C07D207/325; C07D207/327; C07D207/34; C07D209/08; C07D209/42; C07D213/56; C07D213/81; C07D213/82; C07D215/48; C07D215/52; C07D219/04; C07D231/14; C07D231/56; C07D233/90; C07D235/08; C07D237/28; C07D239/26; C07D239/42; C07D241/24; C07D241/44; C07D243/14; C07D249/04; C07D249/06; C07D249/18; C07D261/18; C07D265/36; C07D271/08; C07D277/20; C07D277/56; C07D285/06; C07D295/12; C07D295/185; C07D307/68; C07D307/78; C07D307/79; C07D307/84; C07D307/85; C07D317/60; C07D317/68; C07D319/16; C07D319/18; C07D333/24; C07D333/38; C07D333/40; C07D333/68; C07D333/70; C07D401/06; C07D403/04; C07D405/04; C07D471/04; C07D495/04

JP5505199A
JP10500106A
JP2004518719A
JP4317689B2

WO2000075114A1
WO2002024631A1

Journal of the Chemical Society. Perkin Transactions. 1,2000年,No.18,p.3096-3106
Tetrahedron Letters,1998年,Vol.39,p.497-500
Justus Liebigs Annalen der Chemie,1971年,Vol.743,p.42-9
Journal of Mathematical Chemistry,2001年,Vol.44,p.2638-40
Bulletin of the Korean Chemical Society,2001年,Vol.22, No.4,p.4014

Junji Yuda
Shoji Miwa
Noriyuki Takebayashi

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