Title:
アデノシン核酸塩基編集因子およびそれらの使用
Document Type and Number:
Japanese Patent JP7231935
Kind Code:
B2
Abstract:
The disclosure provides adenosine deaminases that are capable of deaminating adenosine in DNA. The disclosure also provides fusion proteins comprising a Cas9 (e.g., a Cas9 nickase) domain and adenosine deaminases that deaminate adenosine in DNA. In some embodiments, the fusion proteins further comprise a nuclear localization sequence (NLS), and/or an inhibitor of base repair, such as, a nuclease dead inosine specific nuclease (dISN).
Inventors:
Riu, David, Earl.
Gaudelli, Nicole
Gaudelli, Nicole
Application Number:
JP2019506123A
Publication Date:
March 08, 2023
Filing Date:
August 03, 2017
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
C12N15/09; A61K35/74; A61K38/50; A61K45/00; A61K47/64; A61P35/00; A61P43/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/78; C12N15/55; C12N15/62; C12N15/63
Other References:
Nature,2016年04月20日,vol.533, p.420-424
Nature,2017年10月25日,vol.551, p.464-471
Nucl. Acid Res.,2017年01月28日,vol.45, no.6, p.3369-3377
Nature,2017年10月25日,vol.551, p.464-471
Nucl. Acid Res.,2017年01月28日,vol.45, no.6, p.3369-3377
Attorney, Agent or Firm:
Kiyokazu
Previous Patent: Water-soluble cutting fluid
Next Patent: Apparatus and method for controlling laser hyperthermia
Next Patent: Apparatus and method for controlling laser hyperthermia