Title:
アデノウイルスの免疫測定方法及び免疫測定器具
Document Type and Number:
Japanese Patent JP7436274
Kind Code:
B2
Abstract:
An object of the present invention is to provide: a monoclonal antibody that makes it possible that adenovirus contained in a test specimen is detected and measured rapidly, simply, and with high-sensitivity; and an immunoassay for adenovirus and an immunoassay device therefor, for both of which the monoclonal antibody is used. The present invention provides: a monoclonal antibody or an antigen-binding fragment thereof, which undergoes antigen-antibody reaction with a hexon trimer of adenovirus; and an immunoassay and an immunoassay device that are used with the monoclonal antibody.
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Inventors:
Miyazawa Kyo
Kuwahara Sanwa
Kuwahara Sanwa
Application Number:
JP2020073233A
Publication Date:
February 21, 2024
Filing Date:
April 16, 2020
Export Citation:
Assignee:
Denka Company Limited
International Classes:
C07K16/08; G01N33/569
Domestic Patent References:
| JP2001510998A | ||||
| JP2008122372A | ||||
| JP2020505335A |
Foreign References:
| US4487829 |
Other References:
TIMOSHICHEVA, Tatyana A. et al.,Use of hexon as an antigen for the production of monoclonal antibodies capable of detecting multiple adenovirus types,Biologicals,2019年,vol.58,p.44-49
CEPKO, Constance L. et al.,Immunoprecipitation with two-dimensional pools as a hybridoma screening technique: production and characterization of monoclonal antibodies against adenovirus 2 proteins,Virology,1981年,Vol. 110,pp. 385-401
VARGHESE, Robin et al.,Postentry neutralization of adenovirus type 5 by an antihexon antibody,J. Virol.,2004年,Vol. 78,pp. 12320-12332
HONG, Jeong Shin et al.,The amino terminus of the adenovirus fiber protein encodes the nuclear localization signal,Virology,1991年,Vol. 185,pp. 758-767
Fortsas, E. et al.,"Electrophoretic migration of adenovirus hexon under non-denaturing conditions",Virus Res.,1994年,Vol. 31,pp. 57-65
Wu, H. et al.,"Construction and characterization of adenovirus serotype 5 packaged by serotype 3 hexon",J. Virol.,2002年,Vol. 76,pp. 12775-12782
花岡希 ほか,"新型アデノウイルス(53, 54, 56型)に対するイムノクロマトキットの性能評価",感染症学雑誌,2012年,Vol. 86,pp. 425-426
Fujimoto, T. et al.,"Evaluation of a silver-amplified immunochromatography kit for adenoviral conjunctivitis",J. Med. Virol.,2019年,Vol. 91,pp. 1030-1035
CEPKO, Constance L. et al.,Immunoprecipitation with two-dimensional pools as a hybridoma screening technique: production and characterization of monoclonal antibodies against adenovirus 2 proteins,Virology,1981年,Vol. 110,pp. 385-401
VARGHESE, Robin et al.,Postentry neutralization of adenovirus type 5 by an antihexon antibody,J. Virol.,2004年,Vol. 78,pp. 12320-12332
HONG, Jeong Shin et al.,The amino terminus of the adenovirus fiber protein encodes the nuclear localization signal,Virology,1991年,Vol. 185,pp. 758-767
Fortsas, E. et al.,"Electrophoretic migration of adenovirus hexon under non-denaturing conditions",Virus Res.,1994年,Vol. 31,pp. 57-65
Wu, H. et al.,"Construction and characterization of adenovirus serotype 5 packaged by serotype 3 hexon",J. Virol.,2002年,Vol. 76,pp. 12775-12782
花岡希 ほか,"新型アデノウイルス(53, 54, 56型)に対するイムノクロマトキットの性能評価",感染症学雑誌,2012年,Vol. 86,pp. 425-426
Fujimoto, T. et al.,"Evaluation of a silver-amplified immunochromatography kit for adenoviral conjunctivitis",J. Med. Virol.,2019年,Vol. 91,pp. 1030-1035
Attorney, Agent or Firm:
Patent Attorney Corporation Tanikawa International Patent Office