Title:
T-betによるTH2系譜コミットメントの調節
Document Type and Number:
Japanese Patent JP2008528005
Kind Code:
A
Abstract:
The instant invention is based, at least in part, on the identification of a mechanism by which T-bet directly modulates Th2 cytokine production. The present invention pertains to methods of identifying agents that modulate the Tec kinase-mediated interaction of T-bet with GATA-3, as well as methods of use therefore.
Inventors:
Grimshire, Laurie H
Tuabo, Susan Jei
Wang, Yoon Souk
Tuabo, Susan Jei
Wang, Yoon Souk
Application Number:
JP2007552417A
Publication Date:
July 31, 2008
Filing Date:
January 20, 2006
Export Citation:
Assignee:
AVANT IMMUNOTHERAPEUTICS,INC.
International Classes:
C12Q1/48; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P1/00; A61P1/02; A61P3/10; A61P5/14; A61P7/00; A61P7/06; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P17/14; A61P19/02; A61P21/04; A61P25/00; A61P27/02; A61P29/00; A61P31/00; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C12Q1/02; C12Q1/68; C12N15/09
Attorney, Agent or Firm:
Heikichi Odashima