Title:
クロマチンリモデリング物質による染色体機能の調整
Document Type and Number:
Japanese Patent JP2004501620
Kind Code:
A
Abstract:
The present invention concerns a process for modulating the function of a DNA element in a eukaryotic cell, comprising the step of contacting a genomic DNA element, so-called "chromatin responsive element" (CRE), with a compound having a molecular weight of less than approximately 5 KDa, and having the capacity to bind a sequence-specific manner to said CRE, said step of contacting being carried out in conditions permitting chromatin remodeling of the CRE by said compound, wherein said chromatin remodeling of the CRE alters the activity of one or more other DNA elements, so called "modulated DNA elements" in the genome.
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Inventors:
Laemli, Ulrich
Application Number:
JP2002505043A
Publication Date:
January 22, 2004
Filing Date:
June 26, 2001
Export Citation:
Assignee:
UNIVERSITE DE GENEVE
International Classes:
A01H5/00; A01K67/027; A61K31/7115; A61K48/00; A61P35/00; A61P43/00; C07K14/47; C09K11/06; C12N5/10; C12N15/09; C12Q1/68; G01N33/53; G01N33/566; A61K38/00; (IPC1-7): C12N15/09; A01H5/00; A01K67/027; A61K31/7115; A61K48/00; A61P35/00; A61P43/00; C09K11/06; C12N5/10; C12Q1/68; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda