Title:
膵臓ベータ細胞増殖の調整
Document Type and Number:
Japanese Patent JP2014523871
Kind Code:
A
Abstract:
Work described herein provides, in one embodiment, a method for increasing proliferation or replication of pancreatic beta cells in a subject in need thereof, comprising administering to said subject an effective amount of an agent that increases the level or activity of hepatocellular carcinoma-associated protein TD26 (TD26), thereby increasing proliferation or replication of pancreatic beta cells. Such an agent may function by, for example, increasing the level of active TD26 in the subject or by increasing the functional activity of TD26 in the subject.
Inventors:
Melton and Douglas Ey.
E and a pen
E and a pen
Application Number:
JP2014514917A
Publication Date:
September 18, 2014
Filing Date:
June 10, 2012
Export Citation:
Assignee:
President And Fellows オブ Harbored College
International Classes:
A61K45/00; A61K31/7088; A61K38/00; A61K48/00; A61P1/18; A61P3/04; A61P3/10; A61P5/50; A61P43/00; C12N5/071; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/68; C07K14/82; C12N15/09
Domestic Patent References:
| JP2009168820A | 2009-07-30 |
Other References:
JPN6016002956; Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｖｏｌ．３７６, 20080907, ｐ．３８０-３８３
JPN6016002954; Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｖｏｌ．３９８, 20100619, ｐ．２６０-２６５
JPN6016002959; ＤＩＡＢＥＴＥＳ Ｖｏｌ．５４, 2005, ｐ．３６７-３７２
JPN6016002954; Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｖｏｌ．３９８, 20100619, ｐ．２６０-２６５
JPN6016002959; ＤＩＡＢＥＴＥＳ Ｖｏｌ．５４, 2005, ｐ．３６７-３７２
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Natsuki Morishita