Title:
ADOPTIVE IMMUNOTHERAPY FOR TREATING AIDS
Document Type and Number:
Japanese Patent JPS63119428
Kind Code:
A
Abstract:
The invention relates to the use of activated T lymphocytes at a dosage effective in transferring cell mediated imunity against AIDS virus infected cells in vivo, in which: (a) the activated T lymphocytes are specific for an epitope of the AIDS virus and histocompatible with the patient; and (b) the activated T lymphocytes are capable of mediating AIDS virus specific T cell immunity as measured by either of the following assays: (i) a cytotoxicity assay in which the activated T lymphocytes are incubated with the patient's radiolabelled target cells infected with AIDS virus, the release of radiolabel being an indication of lysis of the infected target cells; and (ii) a stimulation assay which measures the ability of the activated T lymphocytes to proliferate and/or produce a lymphokine in response to stimulation with an epitope of the AIDS virus in vitro for preparing a pharmaceutical composition for the treatment of AIDS.
Inventors:
SHIYUU ROTSUKU FUU
JIYOISU ZAARINGU
JIYOISU ZAARINGU
Application Number:
JP23471887A
Publication Date:
May 24, 1988
Filing Date:
September 18, 1987
Export Citation:
Assignee:
ONCOGEN
International Classes:
A61K35/12; A61K35/14; A61K35/26; A61P31/12; A61P31/18; C12N5/07; C12N5/0783; C12Q1/70; A61K39/00; (IPC1-7): A61K35/12
Attorney, Agent or Firm:
Minoru Nakamura (4 outside)