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Title:
AGENT FOR ELIMINATING ACTIVE OXYGEN FREE RADICAL
Document Type and Number:
Japanese Patent JPS6425726
Kind Code:
A
Abstract:

PURPOSE: To obtain a strong eliminating agent for active oxygen free radical (super oxide anion, OH radical or OOH radical) occurring in a metabolic system inn organisms, comprising tannin of condensation type as an active ingredient.

CONSTITUTION: Tannin of condensation type especially (-)epicatechin 3-O-gallate or (-)epigallocatechin 3-O-gallate separated from Rheum spp, tea or Japanese persimmon is used as an active ingredient and pharmaceutically manufactured by using a conventional drug carrier by an ordinary procedure to give the aimed substance. The aimed substance can be prepared into a dosage form such as tablet, pill, capsule, solution or injection and a dose is 20W200mg. An active free radical causes various diseases such as inflammation, carcinogenesis, radiation damage, immunity, cataract, arteriosclerosis, myocardial ischemia, aging, convulsion, cerebral apoplexy an diabetes. The agent can eliminate active oxygen which can not be sufficiently removed by existing vitamins E and C having antioxidation.


Inventors:
Ozaki, Masawaka
Mori, Akitane
Hiramatsu, Midori
Nishioka, Itsuo
Nonaka, Genichiro
Uchida, Shinji
Akashi, Toshihiro
Application Number:
JP1987000269041
Publication Date:
January 27, 1989
Filing Date:
October 24, 1987
Export Citation:
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Assignee:
YUUTOKU YAKUHIN KOGYO KK
International Classes:
A61K31/35; A61K36/18; A61K36/70; A61P3/00; (IPC1-7): A61K31/35; A61K35/78