To obtain a preventing/treating agent for diseases caused by a low adiponectin state by a new mechanism of action.

This preventing/treating agent for diseases caused by the low adiponectin state is provided by containing a compound having an anti-oxidation activity as an active ingredient. Since the preventing/treating agent elevates the production of the adiponectin, it is useful for the prevention and treatment of the diseases caused by the low adiponectin state such as hypoadiponectinemia, glucose tolerance disorder, diabetes mellitus, type 2 diabetes mellitus, insulin resistance syndrome, diabetic complications, hyperglycemia, arteriosclerosis, atherosclerosis, cardiovascular diseases, cerebrovascular accidents, vascular stenosis, peripheral vascular diseases, aneurysm, hyperlipidemia, hypercholesterolemia, obesity, or the like.