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Title:
AGENT FOR OVERCOMING TOLERANCE OF ANTICANCER MEDICINE
Document Type and Number:
Japanese Patent JP2003063989
Kind Code:
A
Abstract:

To provide an agent for overcoming tolerance of anticancer medicine to carcinoma cells by BCRP (Boreal Caribou Research Program) containing the effective ingredients having steroid hormones, compounds having female hormone action or compounds having antagonistic actions against these hormones: and the anticancer medicine containing (A) steroid hormones, compounds having female hormone actions or compounds having antagonistic actions against these hormones and anticancer medicines to which the carcinoma cells are capable of aquire the tolerance.

Pharmacological effects of conventional anticancer medicines could not have been expressed sufficiently, because of the generation of tolerance, while according to the present invention, the effects of anticancer medicines can easily be recovered and administration of the dosage of the anticancer medicines can easily be achieved, as the result that chemotherapy of cancer can possibly be proceeded with which the side-effects thereof are controlled.


Inventors:
Sugimoto, Yoshiichi
Tsukahara, Satomi
Imai, Yasuo
Application Number:
JP2001000252953
Publication Date:
March 05, 2003
Filing Date:
August 23, 2001
Export Citation:
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Assignee:
JAPAN FOUND CANCER RES
International Classes:
C12N15/09; A61K31/56; A61K31/565; A61K31/57; A61K45/00; A61K45/06; A61P35/00; A61P43/00; C07J1/00; C07J17/00; C12N5/10; (IPC1-7): A61K45/00; A61K31/56; A61K31/565; A61K31/57; A61K45/06; A61P35/00; A61P43/00; C12N5/10
Foreign References:
Other References:
JPN6010043414, DOYLE,L.A. et al, "A multidrug resistance transporter from human MCF−7 breast cancer cells", Proc Natl Acad Sci U S A, 1998, Vol.95, No.26, p.15665−70
JPN6010043416, 日馬 幹弘, "Toremifeneの耐性解除効果により著効が得られたCAF耐性乳癌肺転移の1例", 癌と化学療法, 199907, Vol. 26, No. 8, P. 1171−1175
JPN6010043417, DE,V.I. et al, "Modulatory effect of tamoxifen and ICI 182,780 on adriamycin resistance in MCF−7 human breast−cancer", Int J Cancer, 1996, Vol.68, No.3, p.340−8
JPN6010043418, PAYEN,L. et al, "Reversal of MRP−mediated multidrug resistance in human lung cancer cells by the antiprogestatin drug", Biochem Biophys Res Commun, 1999, Vol.258, No.3, p.513−8
JPN6010043420, WANG,E.J. et al, "In vitro flow cytometry method to quantitatively assess inhibitors of P−glycoprotein", Drug Metab Dispos, 2000, Vol.28, No.5, p.522−8
JPN6010043421, FARDEL,O. et al, "The P−glycoprotein multidrug transporter", Gen Pharmacol, 1996, Vol.27, No.8, p.1283−91
Attorney, Agent or Firm:
有賀 三幸 (外6名)