AGENT FOR PREVENTING OR TREATING PERIODONTAL DISEASE, AND ORAL COMPOSITION

Title:

AGENT FOR PREVENTING OR TREATING PERIODONTAL DISEASE, AND ORAL COMPOSITION

Document Type and Number:

Japanese Patent JP2010001228

Kind Code:

A

Abstract:

To provide an agent for preventing or treating periodontal disease, exhibiting high argingipain activity-inhibiting effects, and to provide an oral composition.

The agent for preventing or treating the periodontal disease comprises gabexate mesilate, and a water-soluble nonionic macromolecular material and/or a nonionic surfactant. The oral composition is obtained by formulating the gabexate mesilate, and the water-soluble nonionic macromolecular material and/or the nonionic surfactant. The agent for preventing or treating the periodontal disease exhibits the excellent argingipain activity-inhibiting effects by specifically inhibiting the argingipain of a cysteine protease produced by Porphyromonas gingivalis of a causative bacterium of the periodontal disease in high activity. The oral composition is useful for prevention or treatment of the periodontal disease.

Inventors:

MARUYAMA MASATATSU

Application Number:

JP2008159293A

Publication Date:

January 07, 2010

Filing Date:

June 18, 2008

Export Citation:

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Assignee:

LION CORP

International Classes:

A61K31/235; A61K8/43; A61K8/60; A61K8/73; A61K47/14; A61K47/38; A61P1/02; A61P31/04; A61P43/00; A61Q11/00; A23G4/00; A23L1/30

Other References:

JPN6012022990; 薬剤学６５（１）, 2005, ４３-４７
JPN6012066511; 新化粧品ハンドブック , 20061030, １１９-１２１
JPN6012066512; 今村隆寿: '歯周病菌Ｐｏｒｐｈｙｒｏｍｏｎａｓ　ｇｉｎｇｉｖａｌｉｓトリプシン様システインプロテアーゼ（ジンジパイン）と炎症' 炎症と免疫Ｖｏｌ．１０，　Ｎｏ．３, 200205, Ｐａｇｅ．２３９-２４６
JPN7012005225; 今日の治療薬（１９９６年版） , 199602, ６５３

Attorney, Agent or Firm:

Takashi Kojima
Saori Shigematsu
Katsunari Kobayashi
Takeshi Ishikawa

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