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Title:
AGENT FOR SUPPRESSING FORMATION OF LIPID PEROXIDE
Document Type and Number:
Japanese Patent JPS63130592
Kind Code:
A
Abstract:

NEW MATERIAL:The pyrazolone derivative of formula I and/or formula II [R1 is cycloalkyl, (substituted) aryl or heterocyclic group; R2 is H or alkyl; R3 is heterocyclic group; n is 0 or 1].

EXAMPLE: 1-Phenyl-3-(3-pyridyl)-2-pyrazolin-5-one.

USE: A lipid peroxide-formation inhibiting agent useful as a preventive or remedy for various ischemic diseases, various cerebral diseases, cardiac diseases or peripheral circulation disorder. It is administered at a rate of 1W100mg per dose and 1W3 doses a day by oral administration, 0.01W10mg per dose and 2W5 doses a day by intravenous injection or 1W100mg per dose and 1W3 doses a day by rectal infusion.

PREPARATION: A β-keto acid derivative of formula III (R4 is 1W5C alkyl) is made to react with a hydrazine derivative of formula H2NNH-R1 at 10W200°C optionally in the presence of a solvent such as methanol and a catalyst such as a base.


Inventors:
MORINAKA YASUHIRO
NISHI HIROYOSHI
WATANABE TOSHIAKI
YUKI TOSHIYUKI
SAKURAI YOKO
HAYASHI YOSHIO
FUKUSHIMA NOBUKO
Application Number:
JP27736386A
Publication Date:
June 02, 1988
Filing Date:
November 20, 1986
Export Citation:
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Assignee:
MITSUBISHI CHEM IND
International Classes:
A61K31/44; A61K31/415; A61K31/425; A61K31/4427; A61K31/443; A61P3/06; C07D401/04; C07D401/06; C07D401/14; C07D403/04; C07D403/06; C07D405/04; C07D405/06; C07D405/14; C07D417/04; C07D417/14; (IPC1-7): A61K31/44; C07D401/04; C07D401/06
Attorney, Agent or Firm:
Hasegawa Soji



 
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