アグレカナーゼ分子

Title:

アグレカナーゼ分子

Document Type and Number:

Japanese Patent JP2005515779

Kind Code:

A

Abstract:

Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.

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Inventors:

Christopher Corcoran
Michael Jay Agostino
Edward La Barry
Bethany Freeman
Weilan Zen
Lisa Collins-Lacy
Karl Earl Flannery

Application Number:

JP2003564218A

Publication Date:

June 02, 2005

Filing Date:

January 31, 2003

Export Citation:

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Assignee:

Wyeth

International Classes:

C12N15/09; A61K39/395; A61K45/00; A61P1/00; A61P1/02; A61P1/04; A61P7/00; A61P9/00; A61P11/00; A61P11/06; A61P13/00; A61P17/02; A61P19/00; A61P19/02; A61P19/10; A61P25/00; A61P25/02; A61P25/06; A61P25/14; A61P25/16; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N5/22; C12N9/64; C12P21/02; C12Q1/37; (IPC1-7): C12N15/09; A61K39/395; A61K45/00; A61P1/00; A61P1/02; A61P1/04; A61P7/00; A61P9/00; A61P11/00; A61P11/06; A61P13/00; A61P17/02; A61P19/00; A61P19/02; A61P19/10; A61P25/00; A61P25/02; A61P25/06; A61P25/14; A61P25/16; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/64; C12P21/02; C12Q1/37

Attorney, Agent or Firm:

Mitsuo Tanaka
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita

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