To provide a vaccine containing a Sendai virus vector that encodes the viral protein of an immunodeficiency virus.
The protective immunity to the immunodeficiency virus can be efficiently induced by intranasally administering a Sendai virus encoding the viral protein of the immunodeficiency virus to a macaque monkey. The expression of the antigen gene through the Sendai virus vector was detected in the nasal cavity mucosa and the regional lymph by a vaccination in the nasal cavity, and a significant level of antigen specific cellular immune response was induced. A pathological symptom by vaccination was not seen. A simian immunodeficiency virus was exposed to study the effect after vaccination. As a result, a significant decrease of a viral load in the plasma was found as compared with the control animal. The vaccine is promising as an AIDS virus vaccine.
MATANO TETSURO
KATO ATSUSHI
NAGAI YOSHIYUKI
HASEGAWA MAMORU
NAT INST OF INFECTIOUS DISEASES
JPN7011001216; ＫＡＮＯ， Ｍ． ｅｔ ａｌ: 'Ｉｎｄｕｃｔｉｏｎ ｏｆ ＳＩＶ-Ｓｐｅｃｉｆｉｃ Ｃｅｌｌｕｌａｒ Ｉｍｍｕｎｅ Ｒｅｓｐｏｎｓｅｓ ｂｙ Ｕｓｉｎｇ Ｒｅｃｏｍｂｉｎａｎｔ Ｓｅｎｄａｉ Ｖｉｒａｌ Ｖｅｃｔｏｒ' ７ｔｈ Ｃｏｎｆｅｒｅｎｃｅ ｏｎ Ｒｅｔｒｏｖｉｒｕｓｅｓ ａｎｄ Ｏｐｐｏｒｔｕｎｉｓｔｉｃ Ｉｎｆｅｃｔｉｏｎｓ［ｏｎｌｉｎｅ］ , 20000130, ａｂｓｔｒａｃｔ ８０７［ｒｅｔｒｉｅｖｅｄ ｏｎ ２００１-０６-２７］
JPN5002007302; ＨＡＳＡＮ，Ｍ．Ｋ．: Ｊ．ＧＥＮ．ＶＩＲＯＬ． Ｖ７８ ＰＴ１１, 1997, Ｐ２８１３-２８２０
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto