PURPOSE: To obtain the subject inhibitor giving a stable aqueous solution exhibiting excellent aldose reductase-inhibiting activity and a low toxicity with high solubility in water, containing sulfate derivatives of a compound having phenolic hydroxyl group as an active ingredient.
CONSTITUTION: A sulfate derivative or salt thereof of a compound having phenolic hydroxyl group is contained in the objective drug having aldose reductase- inhibiting property comparable to or higher than a compound having not sulfuric esterified phenolic hydroxyl group as an active ingredient. As the compound having phenolic hydroxyl group, compounds extracted from various plants, such as tannic acid, pentagalloyl glucose expressed by formula I (G is galloyl group, namely 3,4,5-trihydroxybenzoyl expressed by formula II), rutin expressed by formula III, quercetin expressed by formula IV, ellagic acid expressed by formula V or epicatechin expressed by formula VI, are exemplified. Said drug is useful as therapeutic agent of various complications in diabetes mellitus such as cataract, retinopathy, kidney disease or nerve disturbance.
SHOJI TOSHIKATSU
IWAMOTO MASAYA
UCHINO KEIJIRO