PURPOSE: To provide the titled inhibitor composed of 3-methylglutaconic acid or its nontoxic salt, useful for the remedy or prevention of complication of diabetes, and easily producible in the form of injection, etc.
CONSTITUTION: It has been found that 3-methylglutaconic acid of formula or its nontoxic salt (e.g. sodium salt) has aldose reductase inhibiting activity, and that the sodium salt (E-type) gives no toxic symptoms when administered to a mouse at a dose of 400mg/kg by intravenous injection. An aldose reductase inhibitor useful for the remedy or prevention of complication of diabetes can be produced by forming the above agent in the form of tablet, injection, etc. The inhibitor is administered orally or parenterally at a dose of 0.2W1,000mg daily for adult.
KATO KAZUO
SHIMADA NOBUYOSHI
FUJII AKIO
TAKITA TOMOHISA
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