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Title:
ALDOSE REDUCTASE INHIBITOR
Document Type and Number:
Japanese Patent JPS61268182
Kind Code:
A
Abstract:

PURPOSE: To provide the titled inhibitor composed of 3-methylglutaconic acid or its nontoxic salt, useful for the remedy or prevention of complication of diabetes, and easily producible in the form of injection, etc.

CONSTITUTION: It has been found that 3-methylglutaconic acid of formula or its nontoxic salt (e.g. sodium salt) has aldose reductase inhibiting activity, and that the sodium salt (E-type) gives no toxic symptoms when administered to a mouse at a dose of 400mg/kg by intravenous injection. An aldose reductase inhibitor useful for the remedy or prevention of complication of diabetes can be produced by forming the above agent in the form of tablet, injection, etc. The inhibitor is administered orally or parenterally at a dose of 0.2W1,000mg daily for adult.


Inventors:
Aoyama, Takayuki
Kato, Kazuo
Shimada, Nobuyoshi
Fujii, Akio
Takita, Tomohisa
Application Number:
JP1985000109327
Publication Date:
November 27, 1986
Filing Date:
May 23, 1985
Export Citation:
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Assignee:
NIPPON KAYAKU CO LTD
International Classes:
C12N9/99; A61K31/19; A61P3/08; A61P3/10; A61P43/00; C07C57/13; (IPC1-7): A61K31/19; C07C57/13; C12N9/99