Title:
アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法
Document Type and Number:
Japanese Patent JP6770553
Kind Code:
B2
Abstract:
The present invention relates to an alkoxyphenyl derivative capable of synthesizing an oligonucleotide by a quicker liquid phase synthesis method than in the prior art, a protected nucleoside and a protected nucleotide to which the alkoxyphenyl derivative is bonded, a method for producing an oligonucleotide using the same, and a method for selectively removing the alkoxyphenyl derivative moiety and the like.A compound represented by the general formula (1) or a derivative thereof:(In the formula,R each independently represents an optionally substituted alkyl group having 10 to 40 carbons.m represents an integer between 1 and 5. When m is 2 or more, a plurality of ROs may be the same or different.X represents O, S, NH, or NRN.n represents an integer from 1 to 4.RN represents an optionally substituted alkyl group having 1 to 6 carbons.)
Inventors:
Kazuhiro Chiba
Youhei Okada
Umemoto Hideaki
Takuya Ohnaka
Youhei Okada
Umemoto Hideaki
Takuya Ohnaka
Application Number:
JP2018136466A
Publication Date:
October 14, 2020
Filing Date:
July 20, 2018
Export Citation:
Assignee:
Fujimoto Chemical Products Co., Ltd.
International Classes:
C07C69/92; C07D413/04; C07D473/18; C07D473/34; C07F9/6558; C07F9/6561; C07H19/067; C07H19/073; C07H19/173; C07H21/04
Domestic Patent References:
| JP2004262809A | ||||
| JP2007536200A | ||||
| JP49126644A | ||||
| JP49124043A | ||||
| JP2010027525A |
Foreign References:
| WO2004081979A1 | ||||
| WO1999019276A1 | ||||
| US5298652 | ||||
| WO2005118542A1 | ||||
| WO2012157723A1 |
Attorney, Agent or Firm:
Patent Business Corporation Unias International Patent Office