Title:
アルキル置換されたインドロキノキサリン化合物
Document Type and Number:
Japanese Patent JP5038891
Kind Code:
B2
Abstract:
Novel substituted indoloquinoxalines of formula (I wherein R1 is hydrogen or represents one or more similar or different substituents in the positions 7 to 10 selected from the group halogen, lower alkyl/alkoxy, hydroxy, trifluoromethyl, trichloromethyl, trifluoromethoxy, R2 represents similar or different C1-C4 alkyl substituents, X is CO or CH2, Y is OH, NH2, NH—(CH2)n—R3 wherein R3 represents lower alkyl, OH, NH2, NHR4 or NR5R6 wherein R4, R5 and R6 independently are lower alkyl or cyclo-alkyl and n is an integer of from 2 to 4, with the provision that when X is CH2, Y is OH or NH—(CH2)n—OH, and pharmacologically acceptable salts thereof are described. The compounds are useful as drugs for preventing and/or treating autoimmune diseases.
Inventors:
Bergman Jean
Engkivist Robert
Gardin Bengt
Kihilstrom Ingemer
Bjorklund Wolf
Engkivist Robert
Gardin Bengt
Kihilstrom Ingemer
Bjorklund Wolf
Application Number:
JP2007516422A
Publication Date:
October 03, 2012
Filing Date:
May 18, 2005
Export Citation:
Assignee:
Oxypharma Abbey
International Classes:
C07D487/04; A61K31/498; A61K31/4985; A61P19/02; A61P25/00; A61P29/00; A61P37/00; A61P37/06; C07D487/02; C07D
Domestic Patent References:
| JP11501293A | ||||
| JP2003522792A |
Foreign References:
| US20010046996 |
Other References:
ZAWADOWSKI,T. et al,Synthesis of some 6-substituted derivatives of indophenazine with potential pharmacological activity,Acta Poloniae Pharmaceutica,1995年,Vol.52, No.3,p.249-51
SINHA,S. et al,Synthesis of 1-[2/9-substituted indophenazine-6-methylcarbonyl]-3-methyl-4- (substituted benzylidene/methylbenzylidene)-pyrazolin-5- ones as potent CNS and anti-inflammatory agents,Indian Drugs,1988年,Vol.26, No.2,p.77-80
KNOTZ,F. et al,Experiments on the production of antiviral and antimicrobial substances. 6. New 6-substituted indolo[2,3-b]quinoxalines,Scientia Pharmaceutica,1975年,Vol.43, No.4,p.249-60
KNOTZ,F.,N-Dimethylaminoethylindophenazine, a new type of compound with broad antimicrobial reaction spectrum,Scientia Pharmaceutica,1970年,Vol.38, No.1,p.20-5
SINHA,S. et al,Synthesis of 1-[2/9-substituted indophenazine-6-methylcarbonyl]-3-methyl-4- (substituted benzylidene/methylbenzylidene)-pyrazolin-5- ones as potent CNS and anti-inflammatory agents,Indian Drugs,1988年,Vol.26, No.2,p.77-80
KNOTZ,F. et al,Experiments on the production of antiviral and antimicrobial substances. 6. New 6-substituted indolo[2,3-b]quinoxalines,Scientia Pharmaceutica,1975年,Vol.43, No.4,p.249-60
KNOTZ,F.,N-Dimethylaminoethylindophenazine, a new type of compound with broad antimicrobial reaction spectrum,Scientia Pharmaceutica,1970年,Vol.38, No.1,p.20-5
Attorney, Agent or Firm:
Takakichi Hayashi