ALKYLATION OF NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND

Title:

ALKYLATION OF NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND

Document Type and Number:

Japanese Patent JPH05170744

Kind Code:

A

Abstract:

PURPOSE: To provide a method for nucleophilically alkylating a nitrogen- containing aromatic heterocyclic compound with a low toxic reagent by a radical reaction under mild conditions.

CONSTITUTION: A method for alkylating a nitrogen-containing aromatic heterocyclic compound comprises irradiating a mixture of (A) the nitrogen-containing aromatic heterocyclic compound, (B) an alkyl halide and (C) a silane compound having a silicon atom-silicon atom bond with light. As a specific example, the application of the method to a mixture of (A) a lepidine-camphor sulfonic acid salt, (B) 1-iodoadamantane and (C) tetrakis (trimethylsilyl) silane gives 2-(1-adamantyl)-4-methylquinoline in a high yield.

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Inventors:

TOGO HIDEO
YOKOYAMA MASATAKA
HAYASHI KEN

Application Number:

JP35700891A

Publication Date:

July 09, 1993

Filing Date:

December 25, 1991

Export Citation:

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Assignee:

DOW CORNING TORAY SILICONE

International Classes:

B01J31/12; C07B37/04; C07B61/00; C07D213/16; C07D215/04; C07D215/14; C07D277/64; (IPC1-7): B01J31/12; C07B37/04; C07B61/00; C07D213/16; C07D215/04; C07D215/14; C07D277/64

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