Title:
アルキルフルオロアルキルスルホネートによるアルキル化
Document Type and Number:
Japanese Patent JP6574173
Kind Code:
B2
Abstract:
The present invention discloses a process for preparing a chemical compound comprising reacting a nucleophile with an alkyl fluoroalkyl sulfonate in the presence of a base of formula NR1R2R3, wherein R1 and R2 are independently 2-methyipropyl or isopropyl and R3 is —CH(R4)(R5), wherein R4 and R5 are identical or different alkyls that are optionally connected to form a ring. The invention also relates to a process for preparing an alkyl fluoroalkyl sulfonate. The invention further relates to a use of the base in a chemical reaction comprising an alkyl fluoroalkyl sulfonate. The process and uses are suitable for preparing chemical compounds, reactants or intermediates thereof, and in particular for preparing API or reactants, like for example everolimus or reactants for its preparation.
Inventors:
Asimoglu, mulatto
Veach, Gemma
Veach, Gemma
Application Number:
JP2016520793A
Publication Date:
September 11, 2019
Filing Date:
June 18, 2014
Export Citation:
Assignee:
Novartis Age
International Classes:
C07D498/18; C07C303/28; C07C309/65; C07F7/18
Domestic Patent References:
| JP2005281296A | ||||
| JP8502266A | ||||
| JP2001500126A |
Foreign References:
| WO2012066502A1 | ||||
| US20090292118 | ||||
| WO2012103959A1 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Kyoko Tamura
Yasuhito Suzuki
Eiji Katayama
Norio Omori
Kyoko Tamura
Yasuhito Suzuki