To obtain a new compound excellent in effects on preventing the generation of various kinds of ulcers and useful as an antibacterial agent against Helicobacter pyroli, etc.
A compound of formula I {R1, R2 are each a lower alkyl; W is a group of formula II [R3 is an alkenyl; R4 is a lower alkyl, a halogen, etc.; X is O, S, etc.; Y is C, N; (m) is 1-3; (n) is 0-2], etc.,}, e.g. a compound of formula III. The compound of formula I (W is a group of formula II) is obtained by converting a carboxylic acid of formula IV into an acid anhydride in the presence of an activating agent such as diphenylphosphinic chloride and subsequently reacting the acid anhydride with an amine of formula V. The reaction is carried out in the presence of an organic base such as triethylamine as an additive in a solvent such as an aromatic hydrocarbon, e.g. benzene, or an ether compound, e.g. tetrahydrofuran, at a reaction temperature of usually -15°C to the refluxing temperature of the solvent by a mixed acid anhydride method.
UETAKE TOMOHIRO
KOJIMA MITSUHISA
FUKUNISHI HIROTADA
SATO FUMITAKA
