Title:
ALPHA-ALKYLPOLYOLEFIN COMPOUND DERIVATIVE USEFUL FOR TREATMENT OF PSORIASIS
Document Type and Number:
Japanese Patent JPS6084231
Kind Code:
A
Abstract:
The present invention relates to novel alpha -alkyl polyolefinic compounds and to pharmaceuticals containing said compounds. The pharmaceuticals are useful for the treatment of psoriasis. The alpha -alkyl polyolefinic compounds have the structure …… wherein… n is 0 to 3;… R1 to R4 are each independently hydrogen or an alkyl group of from 1 to 5 carbon atoms;… R2 is an alkyl group of from 1 to 5 carbon atoms;… R3 is H, C1-C5 alkyl, cyclo C3-C7 alkyl, C2-C5 alkenyl, cyclo C3-C7 alkenyl, aryl, hydroxy, C1-C5 alkoxy, aryloxy, arylalkoxy, formyl, C1-C6 alkylcarbonyl, C2-C5 alkenylcarbonyl, arylcarbonyl, aryl C1-C5 alkylcarbonyl, aryl C2-C5 alkenylcarbonyl, NR5R5, SR5,… … -O-@-R5,… retinyloxy, retinoyl, retinoyloxy, or …… R5 is H, C1-C20 alkyl, aryl, aralkyl; and… Z is a cycloalkyl, cycloalkenyl or cycloalkadienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group, or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof; and the pharmaceutically-acceptable salts thereof.
Inventors:
BAANAADO ROOBU
HOWAADO JIYOONZU
WANNKITSUTO CHIYAN
HOWAADO JIYOONZU
WANNKITSUTO CHIYAN
Application Number:
JP15568984A
Publication Date:
May 13, 1985
Filing Date:
July 27, 1984
Export Citation:
Assignee:
USV PHARMA CORP
International Classes:
A61K31/01; A61K31/045; A61K31/047; A61K31/07; A61K31/075; A61K31/095; A61K31/11; A61K31/12; A61K31/13; A61K31/185; A61K31/21; A61K31/215; A61K31/22; A61P17/00; C07C1/00; C07C13/23; C07C13/28; C07C15/44; C07C15/50; C07C17/00; C07C25/24; C07C27/00; C07C33/05; C07C33/20; C07C33/28; C07C33/40; C07C35/02; C07C35/48; C07C41/00; C07C43/14; C07C43/215; C07C43/23; C07C45/00; C07C47/225; C07C67/00; C07C69/025; C07C69/608; C07C209/00; C07C211/21; C07C211/28; C07C211/44; C07C313/00; C07C321/18; C07C321/20; C07C401/00; C07C403/00; C07C403/02; C07C403/08; C07C403/10; C07C403/12; C07C403/16; C07C403/18; C07C403/22; (IPC1-7): A61K31/01; A61K31/045; A61K31/075; A61K31/095; A61K31/11; A61K31/12; A61K31/13; A61K31/185; A61K31/21; C07/; C07C13/23; C07C13/28; C07C15/44; C07C15/50; C07C21/24; C07C25/24; C07C33/05; C07C33/20; C07C33/40; C07C35/02; C07C35/48; C07C43/14; C07C43/215; C07C47/21; C07C47/225; C07C49/20; C07C49/587; C07C69/025
Attorney, Agent or Firm:
Ryoji Kawase
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