Title:
α-フェトプロテインペプチドおよびその使用
Document Type and Number:
Japanese Patent JP5073154
Kind Code:
B2
Abstract:
The subject invention addresses the need for methods of treatment and prevention of breast cancer, and other cancers, by providing a peptide of eight to twenty amino acids in length which comprises a hydrophilic analog of an alpha-fetoprotein peptide having SEQ ID NO:6: EMTPVNPG. The peptides may be linear, but are preferably cyclic. The peptides may be provided as dimers or other multimers. A composition comprising the peptide, and antibody that specifically binds to the peptide, a method of reducing estrogen-stimulated growth of cells using the peptides, as well as a method of treating or preventing cancer, such as breast cancer, are also provided. The treatment or prevention method can include the use of tamoxifen therapy in combination with the peptide therapy.
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Inventors:
Andersen, Thomas Tea.
Bennett, James A.
Jacobson, Herbert Eye.
Mesfin, Facil Bee.
Bennett, James A.
Jacobson, Herbert Eye.
Mesfin, Facil Bee.
Application Number:
JP2003513583A
Publication Date:
November 14, 2012
Filing Date:
June 02, 2001
Export Citation:
Assignee:
Albany Medical College
International Classes:
A61K47/26; C07K7/06; A61K31/138; A61K38/00; A61K38/17; A61K51/00; A61K51/08; A61P15/00; A61P15/06; A61P15/18; A61P19/10; A61P21/04; A61P29/00; A61P35/00; A61P37/06; C07K7/08; C07K7/64; C07K14/47; C07K16/18; C07K19/00
Other References:
Biochim Biophys Acta,2000年,Vol.1501,No.1,p.33-43
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita