アルファνインテグリン受容体アンタゴニスト

Japanese Patent JP2004508400

A

The present invention relates to cyclic urea derivatives, their synthesis, and their use as alphav integrinreceptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alphavbeta3 and/or alphavbeta5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammatory arthritis, tumor growth and metastasis.

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Hatsuchinson, Jiyoung H
Lee, Iwen

JP2002526374A

March 18, 2004

September 07, 2001

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MERCK & COMPANY INCOPORATED

A61K31/444; A61K41/00; A61K45/06; A61P3/10; A61P7/00; A61P9/08; A61P17/00; A61P19/02; A61P19/08; A61P27/02; A61P29/00; A61P35/00; A61P35/04; A61P43/00; C07D401/12; C07D471/04; (IPC1-7): C07D471/04; A61K31/444; A61P3/10; A61P7/00; A61P9/08; A61P17/00; A61P19/02; A61P19/08; A61P27/02; A61P29/00; A61P35/00; A61P35/04; A61P43/00

Yoshio Kawaguchi
Mitsuru Inoue
Akio Ichiiri
Makoto Ono
Katsuma Osaki

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