Title:
ALPHA-PHOSPHONOSULPHONATE SQUALENE SYNTHETASE INHIBITOR
Document Type and Number:
Japanese Patent JPH06199879
Kind Code:
A
Abstract:
PURPOSE: To provide the new compound which inhibits the biosynthesis of cholesterol and is useful for treating hyperlipemia, hypercholesterolemia, atherosclerosis or the like.
CONSTITUTION: The compound of formula I [R2 is OR5 or R5a (R5a is H, alkyl, aryl or the like);R3, R5 are each H, alkyl, aryl, cycloalkyl or the like; R4 is H, alkyl, aryl or the like; R1 is lipophilic group having at least 7-carbon atoms; Z is H, halogen, lower alkyl or lower alkenyll, e.g. (E,E)-6,10,14-trimethyl-2- phosphono-5,9,13-pentadecatriene-pentadecatriene-1-sulfonic acid(ester), is obtained, e.g. by reacting the compound of formula II (R13-R15 are each alkyl, aryl or the like) with the compound of formula III (X is Br, Cl or the like).
More Like This:
WO/1992/018462 | BICYCLIC AMIDES AS INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL ACYL TRANSFERASE |
WO/1997/010819 | TREATING NIDDM WITH RXR AGONISTS |
Inventors:
DEIBITSUDO AARU MAGUNIN
SUKOTSUTO EI BIRAA
JIYON KEI DEIKUSON JIYUNIA
AARU MAIKERU ROORENSU
RICHIYAADO BII SARUSUKAI
SUKOTSUTO EI BIRAA
JIYON KEI DEIKUSON JIYUNIA
AARU MAIKERU ROORENSU
RICHIYAADO BII SARUSUKAI
Application Number:
JP27039593A
Publication Date:
July 19, 1994
Filing Date:
October 28, 1993
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO
International Classes:
A61P3/06; A61P9/10; A61P19/10; C07B53/00; C07F9/30; C07F9/32; A61K31/66; C07F9/38; C07F9/40; C07F9/48; C07F9/58; C07F9/59; C07F9/653; C07F9/655; C07F9/6553; C07F9/6584; (IPC1-7): C07F9/30; A61K31/66; C07B53/00; C07F9/32; C07F9/38; C07F9/40
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)