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Title:
ALPHA-PHOSPHONOSULPHONATE SQUALENE SYNTHETASE INHIBITOR
Document Type and Number:
Japanese Patent JPH06199879
Kind Code:
A
Abstract:

PURPOSE: To provide the new compound which inhibits the biosynthesis of cholesterol and is useful for treating hyperlipemia, hypercholesterolemia, atherosclerosis or the like.

CONSTITUTION: The compound of formula I [R2 is OR5 or R5a (R5a is H, alkyl, aryl or the like);R3, R5 are each H, alkyl, aryl, cycloalkyl or the like; R4 is H, alkyl, aryl or the like; R1 is lipophilic group having at least 7-carbon atoms; Z is H, halogen, lower alkyl or lower alkenyll, e.g. (E,E)-6,10,14-trimethyl-2- phosphono-5,9,13-pentadecatriene-pentadecatriene-1-sulfonic acid(ester), is obtained, e.g. by reacting the compound of formula II (R13-R15 are each alkyl, aryl or the like) with the compound of formula III (X is Br, Cl or the like).


Inventors:
DEIBITSUDO AARU MAGUNIN
SUKOTSUTO EI BIRAA
JIYON KEI DEIKUSON JIYUNIA
AARU MAIKERU ROORENSU
RICHIYAADO BII SARUSUKAI
Application Number:
JP27039593A
Publication Date:
July 19, 1994
Filing Date:
October 28, 1993
Export Citation:
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Assignee:
BRISTOL MYERS SQUIBB CO
International Classes:
A61P3/06; A61P9/10; A61P19/10; C07B53/00; C07F9/30; C07F9/32; A61K31/66; C07F9/38; C07F9/40; C07F9/48; C07F9/58; C07F9/59; C07F9/653; C07F9/655; C07F9/6553; C07F9/6584; (IPC1-7): C07F9/30; A61K31/66; C07B53/00; C07F9/32; C07F9/38; C07F9/40
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)