Title:
ALPHAAHALOMETHYLAMINES
Document Type and Number:
Japanese Patent JPS55145641
Kind Code:
A
Abstract:
Compounds of formula I wherein X1 and X2 are each hydrogen or fluorine; R1 is hydrogen, alkylcarbonyl, alkoxycarbonyl or aminoalkylcarbonyl, and three of R2, R3, R4, R5 and R6 are hydrogen, the others being selected from hydroxy, methyl and methoxy. Also disclosed is a process of preparing compounds of formula I in which R1 and X2 are hydrogen and X1 is fluorine and R2, R3, R4, R5 and R6 are various combinations of hydrogen, methyl, ethyl, tert-butyl, halogen, trifluoromethyl, hydroxy, methoxy and methylene dioxy by reacting a corresponding benzyl magnesium halide with fluoroacetonitrile and reducing the resultant ketimine salt.
Inventors:
FUIRITSUPE BEI
MISHIERU YUNKU
FURITSUTSU GERUHARUTO
MISHIERU YUNKU
FURITSUTSU GERUHARUTO
Application Number:
JP5442880A
Publication Date:
November 13, 1980
Filing Date:
April 25, 1980
Export Citation:
Assignee:
MERRELL TORAUDE & CO
International Classes:
A61K31/135; A61K31/16; A61K31/165; A61K31/27; A61P25/18; C07C31/13; C07C67/00; A61K31/13; C07C209/00; C07C209/40; C07C209/52; C07C209/56; C07C209/62; C07C211/29; C07C213/00; C07C215/52; C07C217/60; C07C233/13; C07C237/06; C07C237/08; C07C239/00; C07C271/64; C07D317/58; C07D501/00; A61K; C07C; (IPC1-7): A61K31/13; A61K31/16; A61K31/27; C07C87/28; C07C91/30; C07C93/14; C07C103/365; C07C103/38; C07C125/065