Title:
ε-アミノ基の選択的アシル化
Document Type and Number:
Japanese Patent JP4312828
Kind Code:
B2
Abstract:
The present invention relates to the acylation of proteins. More particularly, the invention relates to a one-step process for selectively acylating the free epsilon -amino group of insulin, insulin analog, or proinsulin in the presence of a free alpha -amino group.
Inventors:
Baker, Jeffrey Clayton
Chen, Victor John
Hank Wire, George Michael
Clio Siunas, Adas Bradas
Brian Allen, Moser
Schumann, Robert Theodore
Chen, Victor John
Hank Wire, George Michael
Clio Siunas, Adas Bradas
Brian Allen, Moser
Schumann, Robert Theodore
Application Number:
JP51696396A
Publication Date:
August 12, 2009
Filing Date:
November 14, 1995
Export Citation:
Assignee:
Eli Lilly and Company
International Classes:
A61K38/28; C07K1/113; C07K1/107; C07K1/13; C07K14/62
Domestic Patent References:
| JP1254699A |
Foreign References:
| FR2687680A1 |
Other References:
FEBS Letters (1980), Vol.120, No.2, p.275-277
Peptides (1992), Vol.13, p.1187-1192
Biochimie (1990), Vol.72, p.671-675
J.Biol.Chem.(1989), Vol.264, No.17, p.10041-10047
J.Biol.Chem.(1982), Vol.257, No.18, p.10624-10630
Peptides (1992), Vol.13, p.1187-1192
Biochimie (1990), Vol.72, p.671-675
J.Biol.Chem.(1989), Vol.264, No.17, p.10041-10047
J.Biol.Chem.(1982), Vol.257, No.18, p.10624-10630
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Minato Saito
Masahiro Nitta
Samejima Mutsumi
Minato Saito
Masahiro Nitta