Title:
選択的グリコシダーゼ阻害剤およびその使用
Document Type and Number:
Japanese Patent JP5380293
Kind Code:
B2
Abstract:
The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Inventors:
David Bocador
Ernest McEchern
Garrett Whitworth
Matthew Macaulay
Julia Heinonen
Keith Stubbs
Ton-Suan Li
Ernest McEchern
Garrett Whitworth
Matthew Macaulay
Julia Heinonen
Keith Stubbs
Ton-Suan Li
Application Number:
JP2009525881A
Publication Date:
January 08, 2014
Filing Date:
August 31, 2007
Export Citation:
Assignee:
Simon Fraser University
International Classes:
C07H9/06; A61K31/7042; A61P1/04; A61P5/14; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/04; A61P17/06; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07H13/06; C12N9/24; C12Q1/25
Other References:
SYNLETT,1997年,Special Issue,pp.435-436
The Journal of Biological Chemistry ,2005年,280(27),pp.25313-25322
Carbohydrate Research,1986年,vol.154,pp.49-62
Tetrahedron,1994年,50(10),pp.3273-3296
Anales Quimica Serie C,1988年,84(1),pp.5-11
The Journal of Biological Chemistry ,2005年,280(27),pp.25313-25322
Carbohydrate Research,1986年,vol.154,pp.49-62
Tetrahedron,1994年,50(10),pp.3273-3296
Anales Quimica Serie C,1988年,84(1),pp.5-11
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Sakurai Yoko
Satoshi Hashimoto
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Sakurai Yoko
Satoshi Hashimoto