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Title:
AMELIORATING AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Document Type and Number:
Japanese Patent JP2010215527
Kind Code:
A
Abstract:

To provide a safe and effective ameliorating agent for COPD having PC-SOD as an active ingredient.

The ameliorating agent for COPD has lecithinized superoxide dismutase represented by formula (I): SOD'(Q-B)m (wherein SOD' is a residue of superoxide dismutase; Q is a chemical crosslink; B is a residue produced by removing the hydrogen atom from the hydroxyl group at the 2-position of the glycerol moiety in lysolecithin; and m is an integer of one or greater which is the average number of lysolecithin molecules bound to one superoxide dismutase molecule) as an active ingredient and is administered intravenously or via inhalation.


Inventors:
Mizushima, Toru
Application Number:
JP2009000061075
Publication Date:
September 30, 2010
Filing Date:
March 13, 2009
Export Citation:
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Assignee:
LTT BIO-PHARMA CO LTD
International Classes:
A61K38/16; A61K9/08; A61K9/72; A61K47/26; A61K47/48; A61P11/00
Domestic Patent References:
JPH0654681A1994-03-01
JPH09117279A1997-05-06
JP2001064199A2001-03-13
JP2001064199A2001-03-13
JPH0654681A1994-03-01
JPH09117279A1997-05-06
Foreign References:
Other References:
JPN6010020776; BARNES,P.J. et al: 'Prospects for new drugs for chronic obstructive pulmonary disease' Lancet Vol.364, No.9438, 2004, p.985-96
JPN6013022058; Morten et al.: 'Extracellular Superoxide Dismutase Polymorphisms, Lung Function, and Chronic Obstructive Pulmonary D' 日本呼吸器学会雑誌 Vol.46 増刊号, 20080510, p.350
JPN6013022060; 星野友昭ら: '抗酸化薬の呼吸器疾患への可能性' 呼吸 Vol.24 No.12, 2005, Page.1009-1014
JPN6010020776; BARNES,P.J. et al: 'Prospects for new drugs for chronic obstructive pulmonary disease' Lancet Vol.364, No.9438, 2004, p.985-96
JPN6013022058; Morten et al.: 'Extracellular Superoxide Dismutase Polymorphisms, Lung Function, and Chronic Obstructive Pulmonary D' 日本呼吸器学会雑誌 Vol.46 増刊号, 20080510, p.350
JPN6013022060; 星野友昭ら: '抗酸化薬の呼吸器疾患への可能性' 呼吸 Vol.24 No.12, 2005, Page.1009-1014
Attorney, Agent or Firm:
草間 攻