Title:
AMIDE DERIVATIVE AS GK ACTIVATOR
Document Type and Number:
Japanese Patent JP2011006435
Kind Code:
A
Abstract:
To provide a glucokinase activator which is useful for the management, treatment, regulation or adjunct treatment of diseases or conditions, where increasing glucokinase activity is beneficial, e.g. for diseases such as impaired glucose tolerance (IGT), syndrome X, type II diabetes, type I diabetes, dyslipidemia, hyperlipidemia, hypertension and obesity.
The compound is expressed by general formula (I), in which R5 in the formula (I) is such as a thiazole, thiadiazole, isothiazole, pyridine and pyrimidine, etc., which may be substituted.
Inventors:
LAU JESPER
KODRA JANOS TIBOR
GUZEL MUSTAFA
SANTOSH KALPATHY CHIDAMBARESWARAN
MJALLI ADNAN M M
ANDREWS ROBERT CARL
POLISETTI DHARMA RAO
KODRA JANOS TIBOR
GUZEL MUSTAFA
SANTOSH KALPATHY CHIDAMBARESWARAN
MJALLI ADNAN M M
ANDREWS ROBERT CARL
POLISETTI DHARMA RAO
Application Number:
JP2010178083A
Publication Date:
January 13, 2011
Filing Date:
August 06, 2010
Export Citation:
Assignee:
NOVO NORDISK AS
International Classes:
C07D213/75; A61K31/16; C07D239/42; A61K31/18; A61K31/426; A61K31/427; A61K31/433; A61K31/4402; A61K31/443; A61K31/4436; A61K31/4439; A61K31/505; A61K45/00; A61K45/06; A61P1/00; A61P1/18; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P9/00; A61P9/10; A61P9/12; A61P43/00; C07D277/20; C07D277/44; C07D277/46; C07D277/48; C07D285/135; C07D405/12; C07D409/12; C07D417/12
Attorney, Agent or Firm:
Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Kocho Chojiro
Naoki Kono
Katsu Sunagawa
Katsumura Hiro
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi
Takenori Masanori
Takuzo Ichihara
Yamashita Gen
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Kocho Chojiro
Naoki Kono
Katsu Sunagawa
Katsumura Hiro
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi
Takenori Masanori
Takuzo Ichihara
Yamashita Gen