Title:
エストロゲン受容体に対するアミドおよびスルホンアミドリガンド
Document Type and Number:
Japanese Patent JP2006508061
Kind Code:
A
Abstract:
The present invention provides estrogen receptor (ER) ligands of structural formula (I) the pharmaceutically acceptable salts, stereoisomers, and prodrugs thereof, and the pharmaceutically acceptable salts of the prodrugs, wherein R1, R2, R3, R4, R5, X, and Q are as defined herein. The invention further provides pharmaceutical compositions comprising the compounds of formula (I), and methods for treating or preventing diseases, disorders, conditions, or symptoms mediated by an ER which comprise administering to a mammalian subject in need of treatment therewith, an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt, stereoisomer, or prodrug thereof, or a pharmaceutically acceptable salt of the prodrug, or a pharmaceutical composition comprising a compound of formula (I), or a pharmaceutically acceptable salt, stereoisomer, or prodrug thereof, or a pharmaceutically acceptable salt of the prodrug. The invention further provides pharmaceutical compositions comprising combinations of the compounds of formula (I) and one or more of sodium fluoride, estrogen, a bone anabolic agent, a growth hormone or growth hormone secretagogue, a prostaglandin agonist/antagonist, and a parathyroid hormone, and methods of treating or preventing diseases, disorders, conditions, or symptoms mediated by an ER comprising the administration of an effective amount of such combination to a mammalian subject in need of treatment therewith.
Inventors:
Kim Barry O'Keefe Cameron
Richard Chessworth
Richard Chessworth
Application Number:
JP2004537389A
Publication Date:
March 09, 2006
Filing Date:
September 08, 2003
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
C07C311/21; A61K31/167; A61K31/18; A61K31/196; A61K31/216; A61K31/34; A61K31/40; A61K31/401; A61K31/4025; A61K31/4164; A61K31/422; A61K31/4402; A61K31/4409; A61K31/445; A61K31/4453; A61K31/472; A61K31/495; A61K31/5375; A61K31/54; A61K31/557; A61K31/565; A61K33/16; A61K38/22; A61K38/27; A61K45/00; A61P1/04; A61P3/04; A61P3/06; A61P3/08; A61P3/14; A61P5/06; A61P5/10; A61P5/14; A61P5/18; A61P5/24; A61P5/30; A61P7/02; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P13/08; A61P15/00; A61P15/02; A61P15/10; A61P15/12; A61P15/18; A61P17/00; A61P17/02; A61P17/08; A61P17/10; A61P17/14; A61P19/02; A61P19/04; A61P19/08; A61P19/10; A61P21/06; A61P25/00; A61P25/02; A61P25/28; A61P29/00; A61P35/00; A61P37/06; A61P39/02; A61P39/06; A61P43/00; C07C233/60; C07C311/29; C07D207/06; C07D207/08; C07D207/16; C07D211/14; C07D211/42; C07D211/44; C07D211/46; C07D213/38; C07D213/40; C07D215/20; C07D215/36; C07D217/02; C07D217/04; C07D233/61; C07D261/10; C07D265/30; C07D295/08; C07D295/092; C07D295/12; C07D295/135; C07D295/185; C07D307/12; C07D307/14; C07D333/34; C07D521/00
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Junji Yuda
Shoji Miwa