Title:
Amide system insulin prodrug
Document Type and Number:
Japanese Patent JP5912112
Kind Code:
B2
Abstract:
Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half lives of at least 10 hours, and more typically greater than 2 hours, 20 hours and less than 70 hours, and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
Inventors:
Dimarchi, Richard, Dee.
Kou, Bing
Chun, Shujiang
Kou, Bing
Chun, Shujiang
Application Number:
JP2013516766A
Publication Date:
April 27, 2016
Filing Date:
June 23, 2011
Export Citation:
Assignee:
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
International Classes:
A61K38/28; A61P3/10
Domestic Patent References:
| JP2005524677A |
Foreign References:
| WO2009099763A1 |
Other References:
Bioconjugate Chem., 2005, Vol.16, p.913-920
FEMS Microbiol.Ecol.,2007 Jul,61(1),p.110-20
Int. Pept. Res. Ther., 2008.08, Vol.14, p.255-262
FEMS Microbiol.Ecol.,2007 Jul,61(1),p.110-20
Int. Pept. Res. Ther., 2008.08, Vol.14, p.255-262
Attorney, Agent or Firm:
Isshiki International Patent Service Corporation
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