Title:
アミロイドーシス治療のためのアミジン誘導体
Document Type and Number:
Japanese Patent JP2005504053
Kind Code:
A
Abstract:
The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited:
Inventors:
Sarifall Robert Jay.
Konshiki
Wu Xiang Fu
Liu Wen Shuo
Konshiki
Wu Xiang Fu
Liu Wen Shuo
Application Number:
JP2003522514A
Publication Date:
February 10, 2005
Filing Date:
September 03, 2002
Export Citation:
Assignee:
Neurochem (International) Limited
International Classes:
A61K31/34; A61K31/136; A61K31/155; A61K31/166; A61K31/167; A61K31/18; A61K31/195; A61K31/20; A61K31/341; A61K31/343; A61K31/40; A61K31/403; A61K31/404; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/42; A61K31/421; A61K31/443; A61K31/4439; A61K31/505; A61P3/10; A61P9/00; A61P21/00; A61P25/28; A61P29/00; A61P43/00; C07C257/18; (IPC1-7): A61K31/155; A61K31/136; A61K31/166; A61K31/167; A61K31/18; A61K31/195; A61K31/20; A61K31/34; A61K31/343; A61K31/40; A61K31/403; A61K31/404; A61K31/4178; A61K31/4184; A61K31/42; A61K31/421; A61K31/443; A61K31/4439; A61K31/505; A61P3/10; A61P9/00; A61P21/00; A61P25/28; A61P29/00; A61P43/00; C07C257/18
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Koichi Niimi
Kazunori Hashimoto
Koichi Niimi