Title:
アミロイド症を処置するためのアミジン誘導体
Document Type and Number:
Japanese Patent JP2006501160
Kind Code:
A
Abstract:
The present invention relates to the use of amidine compounds in the treatment of amyloid related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formulae, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited. Formula I, Formula II, Formula III.
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Inventors:
Richard Earl Tidwell
David Boykin
Robert J. CHALIFOUR
Xianqi KONG
Xinfu WU
Wenshuo LU
David Boykin
Robert J. CHALIFOUR
Xianqi KONG
Xinfu WU
Wenshuo LU
Application Number:
JP2004510719A
Publication Date:
January 12, 2006
Filing Date:
June 09, 2003
Export Citation:
Assignee:
University of North Carolina at Chapel Hill
International Classes:
A61K31/155; A61K31/166; A61K31/18; A61K31/341; A61K31/343; A61K31/40; A61K31/403; A61K31/4045; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/42; A61K31/421; A61K31/423; A61K31/4439; A61K31/444; A61K31/505; A61P1/02; A61P1/04; A61P3/10; A61P7/00; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P13/12; A61P17/02; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P25/02; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/00; A61P31/06; A61P31/08; A61P35/00; A61P35/02; A61P37/08; A61P43/00; C07C257/14; C07C257/18; C07C259/18; C07C279/04; C07D207/335; C07D209/14; C07D209/88; C07D233/20; C07D233/22; C07D233/26; C07D233/42; C07D233/44; C07D233/64; C07D233/84; C07D233/88; C07D235/18; C07D235/20; C07D235/24; C07D235/30; C07D239/26; C07D261/08; C07D263/32; C07D307/52; C07D307/79; C07D307/80; C07D401/04; C07D403/12; C07D403/14; C07D405/04; C07D405/14; C07D409/14; C07D413/04
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima