To obtain an amido derivative that improves a barrier function of the corneal layer of skin, is useful for preventing or curing the skin from chapping, inflaming, or aging and has excellent formulation stability when formulated for external application.
This amido derivative of formula I [R1 is a 1-40C hydrocarbon; R2 is a 1-6C alkylene; R3 is H or a 1-12C alkoxyl; R4 is a divalent 1-39C hydrocarbon; R24 is a 1-22C hydrocarbon; R5 is formula II (R6 is H or a 1-6C hydrocarbon; R7 is a 1-40C hydrocarbon), etc.], for example, a glyceryl ether derivative, is obtained by making a glycidyl ether react with an amine to form an amino alcohol derivative, making an aminocarboxylic derivative react with an acid chloride, etc., to form an amidocarboxylic acid derivative, making the amino alcohol derivative with the amidocarboxylic acid derivative in the presence of a dehydrating agent, etc., in vacuum at temperature in the range of room temperature to 150°C to form a compound of formula III, making the compound of formula III react with a halogenated alkyl derivative to form a compound of formula IV, furthermore making a compound of formula III react with a halogenated epoxide at temperature in the range of room temperature to 150°C and then with an alcohol in the presence of an acid, etc., to form a compound of formula V, and producing an amido derivative from the compound of formula IV and the compound of formula V.
YOSHINO KOJI
YAMAMURO AKIRA
ARAI YOICHI
MEGURO SHINICHI
TOKIMITSU ICHIROU
