Title:
AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS
Document Type and Number:
Japanese Patent JP2016130320
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide amine polymers for use as bile acid sequestrants.SOLUTION: The present invention provides crosslinked amine polymers effective for binding bile salts and removing them from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like. An amine polymer comprises repeat units derived from polymerization of an amine monomer having six, seven or eight possible reaction sites and a crosslinking monomer having two or three possible reaction sites, where the molar ratio of the amine monomer to the crosslinking monomer is in the range from 1:3 to about 1:1.1, and the amine polymer has a binding affinity for bile acids of at least 0.46 mmol/g when measured using an in vitro A assay.SELECTED DRAWING: None
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Inventors:
ERIC CONNOR
KALPESH BIYANI
SCOTT HECKER
INEZ LEES
MANSKY PAUL
MU YONGQI
FALEH SALAYMEH
ZHANG HONGMIN
DAVID BERGBREITER
GRACE QUAKER
COPE MICHAEL JAMES
ELIZABETH GOKA
LEE ANGELA
DEIDRE MADSEN
SHAO JUN
ZHANG XINNAN
KALPESH BIYANI
SCOTT HECKER
INEZ LEES
MANSKY PAUL
MU YONGQI
FALEH SALAYMEH
ZHANG HONGMIN
DAVID BERGBREITER
GRACE QUAKER
COPE MICHAEL JAMES
ELIZABETH GOKA
LEE ANGELA
DEIDRE MADSEN
SHAO JUN
ZHANG XINNAN
Application Number:
JP2016059918A
Publication Date:
July 21, 2016
Filing Date:
March 24, 2016
Export Citation:
Assignee:
ILYPSA INC
International Classes:
C08G73/02; A61K9/16; A61K31/155; A61K31/192; A61K31/216; A61K31/22; A61K31/351; A61K31/366; A61K31/397; A61K31/40; A61K31/403; A61K31/4045; A61K31/427; A61K31/4418; A61K31/4439; A61K31/455; A61K31/47; A61K31/4985; A61K31/505; A61K31/506; A61K31/522; A61K31/575; A61K31/64; A61K31/785; A61K31/787; A61K38/00; A61K38/26; A61K38/28; A61K45/00; A61P1/00; A61P1/16; A61P3/06; A61P3/10; A61P17/04; A61P25/28; C07C211/27; C07C233/36; C07D213/81; C07D233/61
Domestic Patent References:
| JPH08500386A | 1996-01-16 | |||
| JP2007146180A | 2007-06-14 | |||
| JP2007530737A | 2007-11-01 | |||
| JP2010519298A | 2010-06-03 | |||
| JP2009536246A | 2009-10-08 |
Foreign References:
| WO2000038664A2 | 2000-07-06 | |||
| US3692895A | 1972-09-19 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto