Title:
アミノ酸抱合シアノアクリレートポリマー粒子
Document Type and Number:
Japanese Patent JP5663741
Kind Code:
B2
Abstract:
Disclosed are cyanoacrylate polymer particles which comprise an amino acid(s) and have an average particle diameter of less than 1000 nm. The amino acid-containing particles according to the present invention can kill cancer cells by inducing apoptosis-like cell death. The particles have an especially high affinity for cell lines derived from lymphomas such as T-cell lymphoma and B-cell lymphoma. The particles can also exhibit an antiproliferative effect against some kinds of pancreatic cancer-derived cell lines. Therefore, the particles according to the present invention are useful for prevention and/or treatment of cancers.
Inventors:
城武 昇一
吉田 篤司
横田 俊平
遠藤 格
吉田 篤司
横田 俊平
遠藤 格
Application Number:
JP2011502778A
Publication Date:
February 04, 2015
Filing Date:
March 03, 2010
Export Citation:
Assignee:
株式会社ナノカム
International Classes:
C08F22/32; A61K9/14; A61K31/198; A61K31/401; A61K31/405; A61K31/4172; A61K47/32; A61P35/00; A61P35/02
Domestic Patent References:
| JPS5841818A | 1983-03-11 |
Foreign References:
| WO2008003706A1 | 2008-01-10 | |||
| WO2008126846A1 | 2008-10-23 | |||
| WO2004058243A1 | 2004-07-15 |
Other References:
JPN6010019308; Ｗｅｉｓｓ， Ｃ．Ｋ． ｅｔ ａｌ．: 'Ａ Ｒｏｕｔｅ ｔｏ Ｎｏｎｆｕｎｃｔｉｏｎａｌｉｚｅｄ ａｎｄ Ｆｕｎｃｔｉｏｎａｌｉｚｅｄ Ｐｏｌｙ（ｎ-ｂｕｔｙｌｃｙａｎｏａｃｒｙｌａｔｅ） Ｎａｎｏｐａｒｔｉｃｌｅｓ： Ｐｒｅｐａｒａｔｉｏ' Ｍａｃｒｏｍｏｌｅｃｕｌｅｓ Ｖｏｌ． ４０, 2007, ｐ． ９２８-９３８
JPN6010019310; Ｗｅｉｓｓ， Ｃ．Ｌ． ｅｔ ａｌ．: 'Ｃｅｌｌｕｌａｒ Ｕｐｔａｋｅ Ｂｅｈａｖｉｏｒ ｏｆ Ｕｎｆｕｎｃｔｉｏｎａｌｉｚｅｄ ａｎｄ Ｆｕｎｃｔｉｏｎａｌｉｚｅｄ ＰＢＣＡ Ｐａｒｔｉｃｌｅｓ Ｐｒｅｐａｒｅｄ ｉｎ ａ Ｍｉｎｉｅｍｕ' Ｍａｃｒｏｍｏｌｅｃｕｌａｒ Ｂｉｏｓｃｉｅｎｃｅ Ｖｏｌ． ７， ｐ． ８８３-８９６, 2007
JPN6010019310; Ｗｅｉｓｓ， Ｃ．Ｌ． ｅｔ ａｌ．: 'Ｃｅｌｌｕｌａｒ Ｕｐｔａｋｅ Ｂｅｈａｖｉｏｒ ｏｆ Ｕｎｆｕｎｃｔｉｏｎａｌｉｚｅｄ ａｎｄ Ｆｕｎｃｔｉｏｎａｌｉｚｅｄ ＰＢＣＡ Ｐａｒｔｉｃｌｅｓ Ｐｒｅｐａｒｅｄ ｉｎ ａ Ｍｉｎｉｅｍｕ' Ｍａｃｒｏｍｏｌｅｃｕｌａｒ Ｂｉｏｓｃｉｅｎｃｅ Ｖｏｌ． ７， ｐ． ８８３-８９６, 2007
Attorney, Agent or Firm:
Patent business corporation mountain stream international patent firm