アミノ酸誘導体

Japanese Patent JP3563738

B2

An amino acid derivative having an angiotensin I-converting enzyme inhibitor activity, a vasopressin antagonism and an atrial natriuretic peptide hydrolase inhibitor activity, and represented by general formula (I) wherein R<1> represents hydrogen or acyl; R<2> represents hydrogen, lower alkyl, cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl or optionally substituted heteroarylalkyl; m and n represent each independently an integer of 0.1 or 2; and J represents a cyclic group having an angiotensin I-converting enzyme inhibitor activity.

Hitoshi Ikunuma
Shinji Suda
Naoki Yoneda
Makoto Kotake
Kenji Hayashi
Kazutoshi Miyake
Nobuyuki Mori
Mamoru Saito
Toshiyuki Matsuoka
Masayuki Namiki
Takeshi Sudo
Shigeru Sawada

JP52362094A

September 08, 2004

June 10, 1994

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EISAI CO.,LTD.

A61K31/40; A61K31/42; A61K31/44; A61K31/47; A61K31/55; A61K38/05; C07D209/48; C07D223/16; C07D243/12; C07D267/14; C07D281/10; C07D401/06; C07D409/06; C07D471/04; C07D487/04; C07D495/14; C07D498/04; C07D513/04; C07K5/078; (IPC1-7): C07D223/16; A61K31/55; A61K31/553; A61K31/554; A61K38/00; A61P9/04; A61P9/12; A61P43/00; C07D267/14; C07D281/10; C07D471/04; C07D495/14; C07D513/04; C07K5/00

JP4282382A
JP6056790A
JP7506832A
JP7300479A
JP8502746A
JP7503955A
JP7506827A

WO1993005809A1

Timothy P. Burkholder et al., THESYNTHESIS OF 6-AMINO-5-OXO-7-PHENYL-1,4-OXAZEPINES AS CONFORMATIONALLY CONSTRAINED GAUCHE (-) DIP,Bioorganic & Medicinal Chemistry Letters, 1993年,Vol. 3, No. 2, pp. 231-234

Kaoru Furuya
Takahiko Mizobe
Satoshi Furuya
Shinji Mochida

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