Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
AMINO ACID DERIVATIVE
Document Type and Number:
Japanese Patent JPH0242048
Kind Code:
A
Abstract:

NEW MATERIAL: A compd. represented by formula I [wherein n is 0 or 1; R1 is an alkoxycarbonyl, alkanoyl or aroyl; R2 is H or compounded with N bonded along with R1 to form a group represented by formula II (P and Q are each an aromatic system); R3 is an alkyl, or aralkyl; R4 is an alkyl or cycloalkyl; R5 is H, R6 is OH or R5 and R6 form oxo; R4 and R8 are each (CH2)3 or (CH2)4; and R9 is an alkoxycarbonyl or monoalkylcarbamoyl].

EXAMPLE: N2-[3(S)-[[N-(benzyloxycarbonyl)-L-asparaginyl]amino]-2(R)-hydroxy-4- phenylbutyl]-N1-tert-butyl-L-prolinamide.

USE: A medicine for treating or preventing virus infection.

PROCESS: For example, a compd. represented by formula III and an acid represented by formula IV or a reactive derivative thereof are reacted to obtain the compd. represented by the formula I (wherein n is 0).


Inventors:
BARURAJI KURISHIYAN HANDA
PIITAA JIEIMUZU MACHIN
JIYOSEFU AAMUSUTORONGU MAATEIN
SARII RETSUDOSHIYOO
GARESU JIYON TOMASU
Application Number:
JP1989000149265
Publication Date:
February 13, 1990
Filing Date:
June 12, 1989
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
HOFFMANN LA ROCHE
International Classes:
A61K31/13; A61K31/33; A61K31/40; A61K31/401; A61K31/403; A61K31/4035; A61K31/404; A61K31/425; A61K31/426; A61K31/435; A61K31/4427; A61K31/445; A61K31/47; A61K31/472; A61K31/495; A61K38/00; A61P31/12; A61P43/00; C07C237/10; C07C237/22; C07C291/02; C07C311/05; C07C311/18; C07C317/48; C07C323/60; C07D207/16; C07D209/42; C07D209/48; C07D209/52; C07D211/60; C07D215/48; C07D217/26; C07D241/04; C07D277/04; C07D277/06; C07D279/06; C07D401/12; C07D403/12; C07D471/04; C07D521/00; C07K5/02; (IPC1-7): A61K31/13; A61K31/33; A61K31/40; A61K31/425; A61K31/435; A61K31/445; A61K31/47; A61K31/495; A61K37/02; C07C237/10; C07C237/22; C07C311/05; C07C311/18; C07C317/48; C07C323/60; C07D207/16; C07D209/42; C07D209/48; C07D217/26; C07D241/04; C07D277/04; C07D279/06; C07D401/12; C07D471/04; C07D521/00