PURPOSE: To obtain a new amino-β-lactam acid salt useful for producing monolactam bicyclic antibiotics.
CONSTITUTION: A compound of formula I [R2 is H, methyl, ethyl, benzyl, an aryl; (m), (n) are each 1-4 to form a ring, or (m), (n) are each 0 to form a closed chain] is addition-reacted to a slightly soluble compound of formula II [(X-Y) has one to three carbon atoms, can form a system having a double bond or not having a double bond; (a) when the (X-Y) is closed, X is C, O, N, S; Y is methylene; Z is a group formed by removing a H atom from a carboxylic acid, a sulfonic acid or phosphoric acid, or (b) when the (X-Y) is opened, the (X-Y) can contain a double bond; X is H, methyl, hydroxymethyl, thiol; Y is a residue formed by removing a H atom from a sulfonic acid, a phosphoric acid or a sulfamic acid; Z does not exist; when Z does not exit, when R1 exists, R1 is methyl, acetoxymethyl, methoxy, Cl, carbamoyloxy, etc.], to obtain an amino-β-lactam acid salt of formula III.
JIYUAN KABURE KASUTERUBI
ANTONIO RUISU PAROMO KORU
