Title:
ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVE
Document Type and Number:
Japanese Patent JP2013056894
Kind Code:
A
Abstract:
To provide novel anthranilamide and 2-amino-heteroarene carboxamide derivatives useful as cholesteryl ester transfer protein (CETP) inhibitors; methods for producing the same; use thereof as pharmaceuticals; and pharmaceutical compositions including the same.
The novel anthranilamide and 2-amino-heteroarene carboxamide derivatives are compounds typified by 5-chloro-N-(4-cyclopentyl-benzyl)-2-isopropylamino-N-[2-(3-trifluoromethyl-phenyl)-ethyl]-benzamide or N-(4-tert-butyl-benzyl)-N-2-(3,4-dichloro-phenyl)-ethyl-2-methylamino-nicotinamide and represented by formula I.
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Inventors:
CONTE AURELIA
KUEHNE HOLGER
LUEBBERS THOMAS
MATTEI PATRIZIO
MAUGEAIS CYRILLE
MUELLER WERNER
PFLIEGER PHILIPPE
KUEHNE HOLGER
LUEBBERS THOMAS
MATTEI PATRIZIO
MAUGEAIS CYRILLE
MUELLER WERNER
PFLIEGER PHILIPPE
Application Number:
JP2012226826A
Publication Date:
March 28, 2013
Filing Date:
October 12, 2012
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
C07C237/30; A61K31/166; A61K31/192; A61K31/216; A61K31/275; A61K31/381; A61K31/415; A61K31/417; A61K31/425; A61K31/426; A61K31/4418; A61K31/4427; A61K31/455; A61K31/4965; A61K31/50; A61K31/505; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P43/00; C07C231/02; C07C237/32; C07C237/34; C07C237/42; C07C253/30; C07C255/24; C07C255/57; C07C269/06; C07C271/28; C07C303/30; C07C303/40; C07C309/66; C07C311/08; C07D213/61; C07D213/81; C07D213/82; C07D231/12; C07D231/16; C07D233/64; C07D237/24; C07D239/32; C07D241/28; C07D261/14; C07D263/38; C07D275/02; C07D277/20; C07D277/42; C07D333/38; C07D401/12; C07F7/12
Domestic Patent References:
| JP2009526006A | 2009-07-16 | |||
| JP5340745B2 | 2013-11-13 |
Foreign References:
| WO2004020414A1 | 2004-03-11 | |||
| WO2003037865A1 | 2003-05-08 |
Other References:
JPN6011042478; Ｅｄｗａｒｄ Ｌｕｎｔ， Ｃｈｒｉｓｔｏｐｈｅｒ Ｇ． Ｎｅｗｔｏｎ， Ｃｈｒｉｓｔｏｐｈｅｒ Ｓｍｉｔｈ， Ｇｒａｈａｍ Ｐ． Ｓｔｅｖｅｎｓ， Ｍａｌｃｏｌｍ Ｆ． Ｇ． Ｓｔｅｖｅｎｓ， Ｃｏｌ: 'Ａｎｔｉｔｕｍｏｒ ｉｍｉｄａｚｏｔｅｔｒａｚｉｎｅｓ． １４． Ｓｙｎｔｈｅｓｉｓ ａｎｄ ａｎｔｉｔｕｍｏｒ ａｃｔｉｖｉｔｙ ｏｆ ６- ａｎｄ ８-ｓｕｂｓｔｉｔｕｔｅｄ ｉｍｉｄａｚｏ［５，' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ｖｏｌ．３０， Ｎｏ．２, 1987, ｐ．３５７-３&#
Attorney, Agent or Firm:
Patent business corporation Tsukuni
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata