Title:
AMINOALDEHYDE DERIVATIVE
Document Type and Number:
Japanese Patent JPS55354
Kind Code:
A
Abstract:
Hydrolysable acetals and hemiacetals of aminoaldehydes having the formula 1:- R(NHA<1>)rNHA<2>CHO (1> wherein R represents hydrogen or -A<3>CHO; A<1>, A<2> and A<3> independently represent divalent alkylene (including cycloalkylene) groups; and r represents 0 or an integer inhibit cell proliferation and are believed to be useful in the treatment of cancer and tissue and organ rejection and in contraception. Preferred acetals are those of the formula 5:- wherein R<5> represents hydrogen, (CH2)p CHO or n, m and p independently represent integers from 2 to 12; and R<3> and R<4> independently represent alkyl or alkenyl groups containing 1 to 6 carbon atoms and optionally substituted by hydroxy, alkoxy or halogen or R<3> and R<4> together represent an alkylene group containing 2 or 3 carbon atoms. Some, but not all, of the acetals and hemiacetals are novel compounds. The novel compounds include those of formula 1 in which R is hydrogen and r is 1 and those of formula 5 in which R<5> is hydrogen and r is 1.
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Inventors:
KENESU JIYON MAATON
GURAIN OOEN FUIRITSUPUSU
JIYON CHIYAARUZU AREN
KURISUTOFUAA JIYON SUMISU
UIRIAMU KAANITSUKU
GURAIN OOEN FUIRITSUPUSU
JIYON CHIYAARUZU AREN
KURISUTOFUAA JIYON SUMISU
UIRIAMU KAANITSUKU
Application Number:
JP2501379A
Publication Date:
January 05, 1980
Filing Date:
March 02, 1979
Export Citation:
Assignee:
NICHOLAS INT LTD
International Classes:
A61K31/132; A61P35/00; C07C67/00; A61K31/13; C07C213/00; C07C217/40; C07D317/28; (IPC1-7): A61K31/13; C07C93/02; C07C93/12
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