Title:
AMINOALKYL GLUCOSAMINE PHOSPHATE COMPOUND AND USE THEREOF AS ADJUVANT AND IMMUNOEFFECTOR
Document Type and Number:
Japanese Patent JP2010090139
Kind Code:
A
Abstract:
To provide novel aminoalkyl glucosamine phosphate compounds that are adjuvants and immunoeffectors.
The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl(aglycon) group. The compounds are phosphorylated at the 4-position or 6-position carbon on the glucosamine ring and contain three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. The compounds can be used as adjuvants and immunoeffectors.
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Inventors:
JOHNSON DAVID A (US)
SOWELL C GREGORY (US)
SOWELL C GREGORY (US)
Application Number:
JP2009276135A
Publication Date:
April 22, 2010
Filing Date:
December 04, 2009
Export Citation:
Assignee:
CORIXA CORP (US)
International Classes:
C07F9/655; A61K9/10; A61K31/70; A61K31/7028; A61K39/39; A61K47/06; A61K47/10; A61K47/22; A61K47/24; A61K47/34; A61P37/04; C07H15/04; C07H15/14
Domestic Patent References:
| JPS62129292A | 1987-06-11 | |||
| JPS6344588A | 1988-02-25 | |||
| JPS6330495A | 1988-02-09 | |||
| JPS62129292A | 1987-06-11 | |||
| JPS6344588A | 1988-02-25 | |||
| JPS6330495A | 1988-02-09 |
Foreign References:
| EP0224260A2 | 1987-06-03 | |||
| EP0224260A2 | 1987-06-03 |
Attorney, Agent or Firm:
Hatsushi Shimizu