Title:
AMINOALKYL SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE
Document Type and Number:
Japanese Patent JPS57167945
Kind Code:
A
Abstract:
Aminoalkyl-mono or disubstituted naphthalenes represented by the formula wherein R, R1 and R2 each are the same or different members of the group consisting of hydrogen, hydroxy, loweralkoxy or halo, with the limitation that at least one of R, R1 or R2 must be other than hydrogen except in the case where R3 or R4 are phenyl-loweralkyl or substituted phenyl-loweralkyl, or R1 and R2 or R and R1 together can form a methylene bridge; n is 1 to 4; and R3 and R4 are the same or different members of the group consisting of hydrogen, loweralkyl, haloloweralkyl, loweracyl, benzyl, phenyl-loweralkyl, substituted phenyl-loweralkyl or R3 and R4 are taken together to form a piperazino, piperidino or morpholino moiety, and the pharmaceutically acceptable acid addition salts thereof. By their ability to interact specifically with various types of adrenergic and dopaminergic tissue receptors, these compounds are useful as therapeutic agents in the treatment of hypertension.
Inventors:
JIYON EFU DEBAANAAJISU
JIYON JIYAROSURABU KINKURU
MAACHIN UIN
JIYON JIYAROSURABU KINKURU
MAACHIN UIN
Application Number:
JP3185682A
Publication Date:
October 16, 1982
Filing Date:
March 02, 1982
Export Citation:
Assignee:
ABBOTT LAB
International Classes:
C07D295/18; A61K31/13; A61K31/135; A61K31/165; A61K31/495; A61P9/12; C07C67/00; C07C209/00; C07C211/30; C07C213/00; C07C215/64; C07D295/08; C07D295/096; C07D295/185; C07D317/70; (IPC1-7): A61K31/13; A61K31/495; A61K31/535; C07C87/457; C07C91/28; C07D295/08; C07D295/18